To open their 2024-25 season, the New Orleans Saints welcome the Carolina Panthers to the Superdome for an NFC South matchup.'
Virtually nothing went well for Carolina last season. They finished 2-15 in Bryce Young's rookie season and lost both games against the Saints.'
New Orleans failed to reach the postseason but ended on a high note last year. At 5-7 through 12 games, they won four of their final five to earn a winning record.'
Here's a look at the NFL betting lines and my prediction for Saints vs. Panthers in Week 1.'
Saints vs. Panthers Odds
- New Orleans Saints Moneyline: -225
- Carolina Panthers Moneyline: +185
- Game Spread: New Orleans Saints -4.5 (-115)
- Game Over/Under: 40.5 Points