Rams vs. 49ers NFL Week 4 lines, odds, picks: Monday Night Football predictions and best bets from proven model
Rams vs. 49ers NFL Week 4 lines, odds, picks: Monday Night Football predictions and best bets from proven model

An NFC West contest on Monday Night Football has the Los Angeles Rams (2-1) and San Francisco 49ers (1-2) squaring off. Kickoff is set for 8:15 p.m. ET from Levi's Stadium. San Francisco is a 1.5-point favorite in the latest Rams vs. 49ers odds from Caesars Sportsbook, and the over/under for total points scored is 42.5. Before you make any Rams vs. 49ers picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

The model knows San Francisco has been playing dominant and grueling defense thus far. This group is extremely physical and fast, with the numbers to back that up. They are ranked second in the NFL in total yards allowed (227), first in passing yards allowed (148.3), and fourth in rushing yards allowed (78.7). Linebacker Dre Greenlaw is consistently around the ball, leading the team in total tackles (23).'

  
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