Week 6 of the 2022 NFL season has arrived, and to say things are going great for the Pickswise NFL handicappers would be an understatement. This year, our experts boast a 47-34-1 record against the spread, including a winner on Thursday’s Commanders vs Bears contest.
Now, we've included the best bet of the week from 4 of our sharpest NFL experts. So that's 4 NFL Week 6 best bets, all in one place! Let's dive in to this week’s best bets.
Read our'NFL picks for EVERY Week 6 matchup
Howard Bender: Buffalo Bills -3 (+100) over Kansas City Chiefs
The key factor in this game is how the Bills defense matches up against Patrick Mahomes and his weapons. Injuries to safety Jordan Poyer, cornerback Christian Benford and linebacker Tremain Edwards have hampered the Bills in recent weeks, but Poyer and Edmunds are trending up for this week's game. That's going to make things difficult for Kansas City as the Chiefs receivers still look like they are struggling to get on the same page as Mahomes. His work with Kelce is above reproach, but the Bills rank first overall in DVOA against the tight end position, so it's going to come down to effectiveness running the ball and whether or not a secondary pass-catcher can come up big.