Orioles vs. Yankees odds, line, picks: Proven model reveals MLB picks for July 22, 2022 matchup

The Baltimore Orioles (46-46) and the New York Yankees (64-30) will go head-to-head on Friday as the two AL East rivals begin a three-game series coming out of the all-star break. First pitch set for 7:05 p.m. ET at Camden Yards in Baltimore. New York is listed as a -160 favorite (risk $160 to win $100) on the money line in the latest Orioles vs. Yankees odds from Caesars Sportsbook, while the over-under for total runs scored is 9 (see up-to-date'odds for every game this week on our MLB odds page).

Before making any Yankees vs. Orioles pick s, you NEED to check out the MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 280-240 on top-rated MLB money-line picks since the start of the 2021 season, returning over $500 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

The model knows that the Yankees lost seven of their last 10 games before the all-star break but they still have the best record in baseball and a +196 run differential to back it up. That's 95 runs better than the Astros' differential (the next best team in the AL) and 24 runs better than the Dodgers (the best in the NL). New York's 160 home runs so far this season lead baseball with Anthony Rizzo, Giancarlo Stanton and Aaron Judge all over 20 home runs on the year already.

  
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