A Big 12 battle is on tap between the Oklahoma Sooners and the No. 25 Iowa State Cyclones at 7 p.m. ET on Wednesday at the Lloyd Noble Center. Oklahoma is 9-4 overall and 5-2 at home, while the Cyclones are 10-2 overall and 0-1 on the road. The Sooners are favored by 3 points in the latest Oklahoma vs. Iowa State odds from Caesars Sportsbook and the over/under is set at 124.5. Before you make any Iowa State vs. Oklahoma picks and predictions, you'll want to see what the Spo rtsLine Projection Model is saying.
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