The Ohio State Buckeyes have remained firmly at No. 3 in the AP poll amid their 5-0 start. They visit the Michigan State Spartans as 27.5-point favorites in Week 6. Check out our top Ohio State-Michigan State picks below.
Ohio State pushed on a 39-point spread in its 49-10 win over Rutgers last week. The snapped a two-game ATS win streak for the Buckeyes with those victories coming over Wisconsin and Toledo.
Michigan State has lost three straight games both straight up and against the spread. The latest loss came as a 7.5-point underdog against Maryland last week with a 27-13 final score in favor of the Terrapins.
Be sure to check out our college football best bets and all of our Week 6 picks.