The Notre Dame Fighting Irish (5-1) visit L&N Federal Credit Union Stadium to take on the Louisville Cardinals (5-0) on Oct. 7 in Louisville.
Notre Dame is a betting favorite in Week 6, with the spread sitting at -6.5 (-110).
The Notre Dame vs. Louisville Over/Under is 54.5 total points.
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Notre Dame vs Louisville Prediction for Week 6
Based on recent trends, the winning team model predicts Notre Dame will win this game with 68.3% confidence.
Notre Dame vs Louisville Spread Prediction for Week 6
Based on recent against-the-spread trends, the model predicts Notre Dame will cover the spread with 51.4% confidence.
Both predictions factor in up-to-date player injuries for both Notre Dame and Louisville, plus offensive & defensive matchups, recent games and key player performances this season.
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Notre Dame Best Bets & Trends for ATS, Moneyline & Totals
- Notre Dame has hit the Game Total Over in 10 of their last 15 games (+4.55 Units / 28% ROI)
- Notre Dame has hit the Moneyline in 5 of their last 6 away games (+4.00 Units / 23% ROI)
- Notre Dame have covered the Spread in 9 of their last 15 games (+3.50 Units / 21% ROI)
- Notre Dame have covered the 1Q Spread in 8 of their last 13 games (+2.60 Units / 16% ROI)
- Notre Dame have covered the 1H Spread in 8 of their last 13 games (+2.40 Units / 17% ROI)
Louisville Best Bets & Trends for ATS, Moneyline & Totals
- Louisville has hit the Moneyline in 10 of their last 12 games (+8.30 Units / 34% ROI)
- Louisville has hit the 1Q Game Total Under in 9 of their last 11 games (+7.85 Units / 57% ROI)
- Louisville have covered the Spread in their last 7 games at home (+7.00 Units / 91% ROI)
- Louisville has hit the 1H Game Total Under in 8 of their last 11 games (+4.60 Units / 37% ROI)
- Louisville has hit the 1Q Moneyline in 4 of their last 6 games at home (+2.95 Units / 30% ROI)
Best Notre Dame Player Prop Bets Today
We’ve highlighted some favorite college football player prop bets for Notre Dame players for Week 6, looking at profitable historical betting trends:
- Sam Hartman has hit the TD Passes Over in 6 of his last 8 games (+3.65 Units / 32% ROI)
- Audric Estime has hit the Rushing Yards Under in his last 2 games (+2.00 Units / 83% ROI)
- Chris Tyree has hit the Receiving Yards Under in his last 2 games (+2.00 Units / 83% ROI)
- Sam Hartman has hit the Passing Yards Under in his last 2 games (+2.00 Units / 78% ROI)
- Jayden Thomas has hit the Receiving Yards Over in 3 of his last 4 games (+1.80 Units / 38% ROI)
Best Louisville Player Prop Best Bets Today
Top NCAAF player prop bets for Louisville players for Week 6, looking at profitable historical betting trends:
- Ahmari Huggins-Bruce has hit the Receiving Yards Under in his last 4 games (+4.00 Units / 82% ROI)
- Jack Plummer has hit the TD Passes Under in his last 2 games (+2.40 Units / 74% ROI)
- Jawhar Jordan has hit the Rushing Yards Over in 3 of his last 4 games (+1.80 Units / 38% ROI)
- Brock Domann has hit the TD Passes Over in his last game (+1.00 Units / 42% ROI)
Notre Dame Against the Spread (ATS) Record
Notre Dame is 4-1 against the spread this college football season (+2.9 Units / 43.94% ROI).
- Notre Dame is 3-1 when betting on the Moneyline for +2 Units / 10.87% ROI
- Notre Dame is 3-3 when betting the Over for -0.25 Units / -3.82% ROI
- Notre Dame is 3-3 when betting the Under for -0.3 Units / -4.51% ROI
Louisville Against the Spread (ATS) Record
Louisville is 2-2 against the spread this college football season (-0.2 Units / -3.6% ROI).
- Louisville is 4-0 when betting on the Moneyline for +4 Units / 29.3% ROI
- Louisville is 3-2 when betting the Over for +0.8 Units / 14.55% ROI
- Louisville is 2-3 when betting the Under for -1.3 Units / -23.64% ROI
Notre Dame is 11-3 (.786) when having a turnover margin within one of the opposing team since the 2021 season– 4th-best among Power 5 Teams; Average: .497
Notre Dame is 23-4 (.821) when averaging more than 5 yards on first down plays since the 2021 season– 3rd-best in FBS; Average: .508
Notre Dame is 16-3 (.842) when not losing a fumble since the 2021 season– 3rd-best in FBS; Average: .497
Notre Dame is 12-4 (.706) when making 7 or more explosive plays since the 2022 season– 23rd-best in FBS; Average: .520
Louisville is 6-1 (.750) when not losing a fumble since the 2022 season– tied for best among Power 5 Teams; Average: .391
Louisville is 5-2 (.556) when committing less than 60 yards in penalties since the 2022 season– tied for 14th-best among Power 5 Teams; Average: .356
Louisville is 6-2 (.667) when committing less than 60 yards in penalties since the 2022 season– tied for 19th-best in FBS; Average: .439
Louisville is 7-3 (.636) when passing for more than 200 yards since the 2022 season– tied for 27th-best in FBS; Average: .474
Louisville’s QBs has thrown for 1,505 passing yards in 5 games (301.0 YPG) this season — 15th-best among FBS teams. Notre Dame’s defense has allowed just 146.8 passing yards per game this season — fourth-best among FBS defenses.
Louisville’s offense has thrown for 1,505 passing yards in 5 games (301.0 YPG) this season — 15th-best among FBS offenses. Notre Dame’s defense has allowed just 146.8 passing yards per game this season — fourth-best among FBS defenses.