Notre Dame vs Clemson Prediction, Odds & Best Prop Bets – NCAAF, Week 10

The Notre Dame Fighting Irish (7-2) visit Memorial Stadium to take on the Clemson Tigers (4-4) on Nov. 4 in Clemson.

Notre Dame is a betting favorite in Week 10, with the spread sitting at -3 (-115).

The Notre Dame vs. Clemson Over/Under is 44.5 total points.

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Notre Dame vs Clemson Prediction for Week 10

Based on recent trends, the winning team model predicts Notre Dame will win this game with 54.7% confidence.

Notre Dame vs Clemson Spread Prediction for Week 10

Based on recent against-the-spread trends, the model predicts Clemson will cover the spread with 70.5% confidence.

Both predictions factor in up-to-date player injuries for both Notre Dame and Clemson, plus offensive & defensive matchups, recent games and key player performances this season.


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  • Notre Dame has hit the 1H Moneyline in 10 of their last 13 games (+6.50 Units / 4% ROI)
  • Notre Dame has hit the 1Q Moneyline in 10 of their last 13 games (+6.30 Units / 15% ROI)
  • Notre Dame has hit the Game Total Over in 10 of their last 14 games (+5.65 Units / 37% ROI)
  • Notre Dame has hit the Moneyline in 9 of their last 12 games (+5.20 Units / 8% ROI)
  • Notre Dame have covered the Spread in 9 of their last 14 games (+4.60 Units / 30% ROI)

  • Clemson has hit the 1H Moneyline in 6 of their last 7 games at home (+4.50 Units / 12% ROI)
  • Clemson have covered the 1H Spread in 5 of their last 7 games at home (+2.70 Units / 35% ROI)
  • Clemson have covered the 1Q Spread in 5 of their last 7 games at home (+2.35 Units / 27% ROI)
  • Clemson has hit the 1Q Game Total Under in 8 of their last 13 games (+1.95 Units / 12% ROI)
  • Clemson has hit the 1H Game Total Under in 7 of their last 13 games (+1.70 Units / 12% ROI)

Best Notre Dame Player Prop Bets Today

We’ve highlighted some favorite college football player prop bets for Notre Dame players for Week 10, looking at profitable historical betting trends:

  • Sam Hartman has hit the TD Passes Under in 4 of his last 5 games (+3.80 Units / 62% ROI)
  • Audric Estime has hit the Rushing Yards Under in 4 of his last 5 games (+2.70 Units / 44% ROI)
  • Sam Hartman has hit the Passing Yards Over in 7 of his last 11 games (+2.40 Units / 19% ROI)
  • Chris Tyree has hit the Receiving Yards Over in his last 2 games (+2.00 Units / 91% ROI)
  • Jayden Thomas has hit the Receiving Yards Over in 3 of his last 4 games (+1.80 Units / 38% ROI)

Best Clemson Player Prop Best Bets Today

Top NCAAF player prop bets for Clemson players for Week 10, looking at profitable historical betting trends:

  • Beaux Collins has hit the Receiving Yards Under in 6 of his last 7 games (+4.80 Units / 55% ROI)
  • Will Shipley has hit the Rushing Yards Under in 5 of his last 6 games (+3.80 Units / 52% ROI)
  • Cade Klubnik has hit the Passing Yards Over in 4 of his last 5 games (+2.80 Units / 47% ROI)
  • Antonio Williams has hit the Receiving Yards Over in his last 2 games (+2.35 Units / 107% ROI)
  • Cade Klubnik has hit the TD Passes Under in his last 2 games at home (+2.20 Units / 86% ROI)

Notre Dame Against the Spread (ATS) Record

Notre Dame is 6-2 against the spread this college football season (+3.8 Units / 38.38% ROI).

  • Notre Dame is 5-2 when betting on the Moneyline for +1.6 Units / 4.46% ROI
  • Notre Dame is 5-4 when betting the Over for +0.65 Units / 6.6% ROI
  • Notre Dame is 4-5 when betting the Under for -1.5 Units / -15.08% ROI

Clemson Against the Spread (ATS) Record

Clemson is 2-6 against the spread this college football season (-4.6 Units / -51.98% ROI).

  • Clemson is 3-4 when betting on the Moneyline for -8.1 Units / -16.1% ROI
  • Clemson is 3-5 when betting the Over for -2.5 Units / -28.41% ROI
  • Clemson is 5-3 when betting the Under for +1.7 Units / 19.32% ROI

Notre Dame is 24-4 (.828) when averaging more than 5 yards on first down plays since the 2021 season– tied for 3rd-best in FBS; Average: .510

Notre Dame is 24-4 (.828) when rushing more than 30 times since the 2021 season– 4th-best in FBS; Average: .522

Notre Dame is 24-2 (.889) when scoring 22 or more points since the 2021 season– 3rd-best in FBS; Average: .623

Notre Dame was undefeated (5-0) when intercepting at least 1 pass in the 2022 season– tied for best among Power 5 Teams; Average: .631

Clemson was 9-1 (.750) when converting 55% or more of its red zone chances into touchdowns in the 2022 season– tied for 2nd-best among Power 5 Teams; Average: .426

Clemson is 12-1 (.800) when not throwing an interception since the 2021 season– 2nd-best among Power 5 Teams; Average: .484

Clemson is 12-3 (.706) when making 7 or more explosive plays since the 2022 season– tied for 22nd-best in FBS; Average: .526

Clemson is 5-2 (.714) when not losing a fumble since the 2022 season– tied for 23rd-best in FBS; Average: .492

Clemson’s WRs has gained 1,316 yards on 107 receptions (just 12.3 YPR) this season — third-worst among ACC WRs. Notre Dame’s defense has allowed just 10.2 Yards Per Reception this season — 12th-best among FBS defenses.

Clemson’s TEs has 28 receptions in 7 games (4.0 per game) this season — third-best among ACC TEs. Notre Dame’s defense has allowed just 2.3 receptions per game to TEs this season — tied for 28th-best among FBS defenses.

  
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