College football stages its first big must-see showdown of the 2022 season when the No. 2 Ohio State Buckeyes and the No. 5 Notre Dame Fighting Irish collide in the teams' season opener on Saturday at Ohio Stadium in Columbus. The Buckeyes are coming off a season in which they did not win the Big Ten title for the first time since 2016. Meanwhile the Fighting Irish are playing their first game under new head coach Marcus Freeman.'
Kickoff is 7:30 p.m. ET. The Buckeyes are 17-point favorites in the latest Ohio State vs. Notre Dame odds from Caesars Sportsbook, while the over/under for total points scored is 59. (See up-to-date'odds for every game this week on our college football odds page.)
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