Week 6 kicks off with an NFC West showdown between the San Francisco 49ers (2-3) and Seattle Seahawks (3-2) on Thursday Night Football. Both teams are coming off straight-up losses as favorites of 7 or more points.
A couple of No. 1 overall picks meet in London Sunday as QB Trevor Lawrence and the Jacksonville Jaguars (1-4) take on QB Caleb Williams and the Chicago Bears (3-2). The Bears have won and covered back-to-back games while going 2-0 to the Over.
Sunday’s action continues with the top 2 running QBs in the NFL going head-to-head as Lamar Jackson and the Baltimore Ravens (3-2) host Jayden Daniels and the Washington Commanders (4-1). The Tampa Bay Buccaneers (3-2) continue divisional play when they visit the New Orleans Saints (2-2 before MNF), and the Cleveland Browns (1-4) look to snap a 3-game straight-up/against-the-spread skid at the Philadelphia Eagles (2-2).