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The Super Bowl odds continue to move every week, and the 14-game Week 5 slate features several highly impactful matchups.
We'll round up our betting experts' NFL Week 5 predictions throughout the week as we look to get the best of the odds from our best NFL betting sites.
The Kansas City Chiefs remain undefeated and the Super Bowl favorites. The Baltimore Ravens climbed the rankings with Sunday night's statement beatdown of the Buffalo Bills. And the Minnesota Vikings are the most surprising 4-0 team as we prepare to cross over the quarter-pole of the season.
All three are favorites by the NFL Week 5 odds.
The week starts with Thursday Night Football and Mike Spector's Buccaneers vs. Falcons early picks as they battle for the NFC South lead.
NFL picks & predictions Week 5
Our NEW  ;NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!
- Buccaneers vs. Falcons early picks (TNF)
- Buccaneers vs. Falcons prediction
- Buccaneers vs. Falcons player prop bets
- Buccaneers vs. Falcons TNF parlay
- Baker Mayfield TNF player prop bets
- Bijan Robinson TNF player prop bets
- Anytime touchdown scorer predictions for TNF
- First touchdown scorer predictions for TNF
- Jets vs. Vikings early picks (London)
- Jets vs. Vikings prediction
- Jets vs. Vikings player prop bets
- Aaron Rodgers player prop bets
- Justin Jefferson touchdown picks
- Ravens vs. Bengals player prop bets
- Ja'Marr Chase touchown picks
- Jayden Daniels player prop bets
- Bills vs. Texans player prop bets
- Cowboys vs. Steelers early picks (SNF)
- Cowboys vs. Steelers prediction
- Cowboys vs. Stee lers SNF player prop bets
- Cowboys vs. Steelers SNF parlay
- Dak Prescott SNF player prop bets
- Justin Fields SNF player prop bets
- Anytime touchdown scorer predictions for SNF
- First touchdown scorer predictions for SNF
- Saints vs. Chiefs early picks (MNF)
- Saints vs. Chiefs prediction
- Saints vs. Chiefs MNF player prop bets
Don't miss the rest of our Week 5 NFL picks. Listed odds for all games via bet365 unless stated otherwise.
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NFL odds for Thursday
- When: Thursday, Oct. 3 – 8:15 p.m. ET
- Where: Mercedes-Benz Stadium, Atlanta
- How to watch: Prime Video
- Moneyline: Buccaneers +105 | Falcons -125
- Spread: Buccaneers +1.5 (-110) | Falcons -1.5 (-110)
- Total: 43.5 (-110/-110)
NFL odds for Sunday
- When: Sunday, Oct. 6 – 9:30 a.m. ET
- Where: Tottenham Hotspur Stadium, London
- How to watch: NFL Network
- Moneyline: Jets +120 | Vikings -140
- Spread: Jets +2.5 (-110) | Vikings -2.5 (-110)
- Total: 40.5 (-110/-110)
- When: Sunday, Oct. 6 – 1 p.m. ET
- Where: Gillette Stadium, Foxborough, Mass.
- How to watch: FOX
- Moneyline: Dolphins -120 | Patriots +100
- Spread: Dolphins -1 (-110) | Patriots +1 (-110)
- Total: 36.5 (-110/-110)
- When: Sunday, Oct. 6 – 1 p.m. ET
- Where: Paycor Stadium, Cincinnati
- How to watch: CBS
- Moneyline: Ravens -150 | Bengals +125
- Spread: Ravens -2.5 (-110) | Bengals +2.5 (-110)
- Total: 51 (-110/-110)
- When: Sunday, Oct. 6 – 1 p.m. ET
- Where: NRG Stadium, Houston
- How to watch: CBS
- Moneyline: Bills -105 | Texans -115
- Spread: Bills +1 (-110) | Texans -1 (-110)
- Total: 46.5 (-110/-110)
- When: Sunday, Oct. 6 – 1 p.m. ET
- Where: Northwest Stadium, Landover, Md.
- How to watch: FOX
- Moneyline: Browns +145 | Commanders -170
- Spread: Browns +3 (+100) | Commanders -3 (-120)
- Total: 44 (-110/-110)
- When: Sunday, Oct. 6 – 1 p.m. ET
- Where: EverBank Stadium, Jacks onville
- How to watch: CBS
- Moneyline: Colts +125 | Jaguars -150
- Spread: Colts +2.5 (+100) | Jaguars -2.5 (-120)
- Total: 46 (-110/-110)
- When: Sunday, Oct. 6 – 1 p.m. ET
- Where: Soldier Field, Chicago
- How to watch: FOX
- Moneyline: Panthers +160 | Bears -190
- Spread: Panthers +4 (-110) | Bears -4 (-110)
- Total: 42.5 (-110/-110)
- When: Sunday, Oct. 6 – 4:05 p.m. ET
- Where: Empower Field at Mile High, Denver
- How to watch: FOX
- Moneyline: Raiders +125 | Broncos -150
- Spread: Raiders +2.5 (+100) | Broncos -2.5 (-120)
- Total: 36.5 (-110/-110)
- When: Sunday, Oct. 6 – 4:05 p.m. ET
- Where: Levi's Stadium, Santa Clara, Calif.
- How to watch: FOX
- Moneyline: Cardinals +275 | 49ers -350< /li>
- Spread: Cardinals +7.5 (-110) | 49ers -7.5 (-110)
- Total: 50.5 (-110/-110)
- When: Sunday, Oct. 6 – 4:25 p.m. ET
- Where: Lumen Field, Seattle
- How to watch: CBS
- Moneyline: Giants +220 | Seahawks -270
- Spread: Giants +6 (-110) | Seahawks -6 (-110)
- Total: 42 (-110/-110)
- When: Sunday, Oct. 6 – 4:25 p.m. ET
- Where: SoFi Stadium, Inglewood, Calif.
- How to watch: CBS
- Moneyline: Packers -190 | Rams +160
- Spread: Packers -3.5 (-110) | Rams +3.5 (-110)
- Total: 48 (-110/-110)
- When: Sunday, Oct. 6 – 8:20 p.m. ET
- Where: Acrisure Stadium, Pittsburgh
- How to watch: NBC/Peacock
- Moneyline: Cowboys +120 | Steelers -140
- Spread: Cowboys +2.5 (-110) | Steelers -2.5 (-110)
- Total: 43 (-110/-110 )
NFL odds for Monday
- When: Monday, Oct. 7 – 8:15 p.m. ET
- Where: GEHA Field at Arrowfield Stadium, Kansas City
- How to watch: ESPN
- Moneyline: Saints +200 | Chiefs -245
- Spread: Saints +5.5 (-110) | Chiefs -5.5 (-110)
- Total: 42.5 (-110/-110)
NFL picks roundup: Week 5
- Anytime touchdown scorer predictions
- Touchdown parlay Week 5
- NFL survivor picks
- NFL ATS picks Week 5
- NFL upset picks Week 5
- NFL predictions & best bets Week 5
- NFL parlay picks Week 5
- NFL player props Week 5
NFL betting odds pages
| Super Bowl Odds | NFL MVP Odds | NFL Offensive Player of the Year Odds |
| NFL Defensive Player of the Year Odds | NFL Offensive Rookie of the Year Odds | NFL Defensive Rookie of the Year Odds |
| NFL Coach of the Year Odds | NFL Comeback Player of the Year Odds | NFL Win Totals Odds |
| NFL Playoff Odds | NFL Draft Odds |
Here are our best NFL betting sites:
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- DraftKings Promo Code | Read our DraftKings Review
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