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Week 4 is our last week before byes begin. The 16-game slate will conclude with another doubleheader of Monday Night Football odds.
Our NFL Week 4 predictions round up all of our NFL betting experts' top picks against the NFL Week 4 odds, beginning with Mike Spector's Cowboys vs. Giants early picks.
As always, the Kansas City Chiefs enter the week as consensus favorites by the Super Bowl odds across our best NFL betting sites. They'll play the Los Angeles Chargers on Sunday afternoon.
The marquee game of Week 4 has the Baltimore Ravens as short home favorites by the Sunday Night Football odds against the Buffalo Bills.
NFL picks & predictions Week 4
Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!
- Cowboys v s. Giants early picks
- Cowboys vs. Giants prediction
- Cowboys vs. Giants player props
- Cowboys vs. Giants parlay
- Dak Prescott player props
- Malik Nabers player props
- Anytime touchdown scorer predictions for TNF
- First touchdown scorer predictions for TNF
- Vikings vs. Packers player props
- Broncos vs. Jets player props
- Chiefs vs. Chargers player props
- Bills vs. Ravens early picks
- Bills vs. Ravens prediction
- Bills vs. Ravens player props
- Bills vs. Ravens parlay
- Josh Allen player props
- Lamar Jackson player props
- Anytime touchdown scorer predictions for SNF
- First touchdown scorer predictions for SNF
- Titans vs. Dolphins early picks
- Titans vs. Dolphins prediction
- Titans vs. Dolphins player props
- Seahawks vs. Lions early picks
- Seahawks vs. Lions prediction
- Sea hawks vs. Lions player props
Don't miss the rest of our Week 4 NFL picks. Listed odds for all games via bet365 unless stated otherwise.
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NFL odds for Thursday
- When: Thursday, Sept. 26 – 8:15 p.m. ET
- Where: MetLife Stadium, East Rutherford, N.J.
- How to watch: Prime Video
- Moneyline: Cowboys -210 | Giants +175
- Spread: Cowboys -4.5 (-110) | Giants +4.5 (-110)
- Total: 44 (-110/-110)
NFL odds for Sunday
- When: Sunday, Sept. 29 – 1 p.m. ET
- Where: Mercedes-Benz Stadium, Atlanta
- How to watch: FOX
- Moneyline: Saints +105 | Falcons -125
- Spread: Saints +1.5 (-110) | Falcons -1.5 (-110)
- Total: 42,5 (-110/-110)
- When: Sunday, Sept. 29 – 1 p.m. ET
- Where: Soldier Field, Chicago
- How to watch: FOX
- Moneyline: Rams +135 | Bears -160
- Spread: Rams +3 (-110) |Bears -3 (-110)
- Total: 41 (-110/-110)
- When: Sunday, Sept. 29 – 1 p.m. ET
- Where: Lambeau Field, Green Bay, Wisc.
- How to watch: CBS
- Moneyline: Vikings +120 | Packers -140
- Spread: Vikings +2.5 (+100) | Packers -2.5 (-120)
- Total: 43.5 (-110/-110)
- When: Sunday, Sept. 29 – 1 p.m. ET
- Where: Lucas Oil Stadium, Indianapolis
- How to watch: CBS
- Moneyline: Steelers -125 | Colts +105
- Spread: Steelers -1.5 (-110) | Colts +1.5 (-110)
- Total: 40 (-110/-110)
- When: Sunday, Sept. 29 – 1 p.m. ET
- Where: MetLife Stadium, East Rutherford, N.J.
- How to watch: FOX
- Moneyline: Broncos +265 | Jets -330
- Spread: Broncos +7 (-105) | Jets -7 (-115)
- Total: 38.5 (-110/-110)
- When: Sunday, Sept. 29 – 1 p.m. ET
- Where: Raymond James Stadium, Tamp a, Fla.
- How to watch: FOX
- Moneyline: Eagles -135 | Buccaneers +115
- Spread: Eagles -2.5 (-110) | Buccaneers +2.5 (-110)
- Total: 45 (-110/-110)
- When: Sunday, Sept. 29 – 1 p.m. ET
- Where: Bank of America Stadium, Charlotte
- How to watch: FOX
- Moneyline: Bengals -210 | Panthers +175
- Spread: Bengals -4.5 (-110) | Panthers +4.5 (-110)
- Total: 47.5 (-110/-110)
- When: Sunday, Sept. 29 – 1 p.m. ET
- Where: NRG Stadium, Houston
- How to watch: CBS
- Moneyline: Jaguars +210 | Texans -260
- Spread: Jaguars +6 (-110) | Texans -6 (-110)
- Total: 45.5 (-110/-110)
- When: Sunday, Sept. 29 – 4:05 p.m. ET
- Where: State Farm Stadium, Glendale, Ariz.
- How to watch: FOX
- Moneyline: Commanders +160 | Car dinals -190
- Spread: Commanders +4 (-110) | Cardinals -4 (-110)
- Total: 50.5 (-110/-110)
- When: Sunday, Sept. 29 – 4:05 p.m. ET
- Where: Levi's Stadium, Santa Clara, Calif.
- How to watch: FOX
- Moneyline: Patriots +390 | 49ers -525
- Spread: Patriots +10 (-110) | 49ers -10 (-110)
- Total: 39.5 (-110/-110)
- When: Sunday, Sept. 29 – 4:25 p.m. ET
- Where: Allegiant Stadium, Las Vegas
- How to watch: CBS
- Moneyline: Browns -105 | Raiders -115
- Spread: Browns +1 (-110) | Raiders -1 (-110)
- Total: 37.5 (-110/-110)
- When: Sunday, Sept. 29 – 4:25 p.m. ET
- Where: SoFi Stadium, Inglewood, Calif.
- How to watch: CBS
- Moneyline: Chiefs -425 | Chargers +325
- Spread: Chiefs -8 (-110) | Chargers +8 (-110)
- Total: 39 (-110/-110)
- When: Thursday, Sept. 26 – 8:15 p.m. ET
- Where: M&T Bank Stadium, Baltimore
- How to watch: NBC
- Moneyline: Bills +115 | Ravens -135
- Spread: Bills +2 (-110) | Ravens -2 (-110)
- Total: 45 (-110/-110)
NFL odds for Monday
- When: Monday, Sept. 30 – 7:30 p.m. ET
- Where: Hard Rock Stadium, Miami Gardens, Fla.
- How to watch: ESPN
- Moneyline: Titans -110 | Dolphins -110
- Spread: Titans -1 (-105) | Dolphins +1 (-115)
- Total: 37 (-110/-110)
- When: Monday, Sept. 30 – 8:15 p.m. ET
- Where: Ford Field, Detroit
- How to watch: ABC
- Moneyline: Seahawks +175 | Lions -210
- Spread: Seahawks +4 (-110) | Lions -4 (-110)
- Total: 46.5 (-110/-110)
NFL picks roundup: Week 4
- NFL survivor picks
- NFL ATS picks Week 4
- NFL upset picks
- NFL best bets Week 4
- NFL parlay picks Week 4
- NFL player props Week 4
NFL feature picks
- Vikings odds and futures picks
- NFC South odds
- Marvin Harrison Jr. Rookie of the Year odds
- Comparing your team's Super Bowl odds against Harvard acceptance rate
- NFL power rankings & Super Bowl odds
- NFL rookie QBs and their 2024 OROY odds
- NFL awards odds
- NFL division winners
- 5 under-25 QBs with best NFL MVP odds
- Which of the 5 highest paid NFL players are getting the best MVP odds?
NFL betting odds pages
| Super Bowl Odds | NFL MVP Odds | NFL Offensive Player of the Year Odds |
| NFL Defensive Player of the Year Odds | NFL Offensive Rookie of the Year Odds | NFL Defensive Rookie of the Year Odds |
| NFL Coach of the Year Odds | NFL Comeback Player of the Year Odds | NFL Win Totals Odds |
| NFL Playoff Odds | NFL Draft Odds |
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