Week 1 of the 2024 NFL regular season is nearly in the books, and what a week it’s been. We had massive upsets, close games galore and exciting plays around the league. How will Week 2 deliver an encore? Well, it should begin with a bang, as Thursday Night Football features the Buffalo Bills heading to Miami to take on the Dolphins in a pivotal AFC E ast showdown.
Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also, make sure to check out our NFL best bets page for our top picks. For now, let’s break down the NFL Week 2 opening lines and give our best early bet to make.''
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NFL Week 2 opening lines and odds'
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- Buffalo Bills +1.5 (-115) vs Miami Dolphins -1.5 (-105) – Thursday Night Football''
- Indianapolis Colts -3 (-110) vs Green Bay Packers +3 (-110)'
- Las Vegas Raiders +8 (-110) vs Baltimore Ravens -8 (-110) '
- New Orleans Saints +6.5 (-110) vs Dallas Cowboys -6.5 (-110)''
- Seattle Seahawks -3 (-110) vs New England Patriots +3 (-110)'''
- San Francisco 49ers -5.5 (-115) vs Minnesota Vikings +5.5 (-105)'
- Los Angeles Chargers -5.5 (-110) vs Carolina Panthers +5.5 (-110)''
- New York Jets -4 (-110) vs Tennessee Titans +4 (-110)
- New York Giants +2.5 (-110) vs Washington Commanders -2.5 (-110)''
- Cleveland Browns +3 (-105) vs Jacksonville Jaguars -3 (-115)''
- Tampa Bay Buccaneers +6.5 (-110) vs Detroit Lions -6.5 (-110)'
- Las Angeles Rams -1.5 (-110) vs Arizona Cardinals +1.5 (-110)
- Cincinnati Bengals +6 (-110) vs Kansas City Chiefs -6 (-110)
- Pittsburgh Steelers -3 (-110) vs Denver Broncos +3 (-110)'
- Chicago Bears +6.5 (-110) vs Houston Texans -6.5 (-110) — Sunday Night Football''
- Atlanta Falcons +6 (-110) vs Philadelphia Eagles -6 (-110) — Monday Night Football