Week 18 of the 2023 NFL season is on the immediate horizon. Yes, just 1 week remains. Division titles will be determined and the playoff lineup will be set following Sunday's action. It doesn't get any bigger than this when it comes to regular-season competition. The upcoming week is headlined by a huge showdown for the AFC East title between Buffalo and Miami, while it also includes Texans vs Colts and Rams vs 49ers.'
Make sure you check out our NFL predictions as we add our picks on the side and total for every game. For now, let’s break down the NFL Week 18 opening lines and give our best early bet to make.
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NFL Week 18 opening lines and odds
Odds available at DraftKings Sportsbook at time of publishing.'