This season at BettingPros, we're asking some of our experts to give leans and top picks for every game on the NFL slate. Here are all of their leans, picks, best bets and predictions for Week 16.
View our Pick of the Day in the BettingPros mobile app (free!) >>
Week 16 Spread Leans for Each Game
| Home Team | Away Team | Home Spread | Fitzmaurice | Freedman | Santora | MacMillan | Wolbransky | Greer |
| NYJ | JAC | -1 | NYJ | JAX | JAC | NYJ | JAX | NYJ |
| BAL | ATL | -7.5 | BAL | BAL | BAL | BAL | BAL | ATL |
| CAR | DET | 2.5 | CAR | DET | CAR | CAR | DET | DET |
| CHI | BUF | 9 | CHI | BUF | BUF | CHI | BUF | CHI |
| CLE | NO | -2.5 | CLE | CLE | CLE | CLE | CLE | CLE |
| KC | SEA | -9.5 | KC | KC | KC | SEA | SEA | KC |
| MIN | NYG | -3.5 | NYG | MIN | MIN | NYG | NYG | MIN |
| NE | CIN | 3.5 | CIN | NE | CIN | CIN | CIN | NE |
| TEN | HOU | -5 | TEN | TEN | TEN | TEN | HOU | TEN |
| SF | WAS | -7 | SF | SF | WAS | WAS | WAS | WAS |
| DAL | PHI | -5 | PHI | PHI | DAL | PHI | PHI | PHI |
| PIT | LV | -3 | PIT | LV | LV | LV | PIT | KLV |
| MIA | GB | -4 | MIA | MIA | MIA | GB | MIA | MIA |
| LAR | DEN | 2.5 | LAR | LAR | LAR | DEN | DEN | LAR |
| ARI | TB | 6.5 | ARI | ARI | TB | TB | TB | TB |
| IND | LAC | 4 | IND | IND | LAC | IND | LAC | LAC |
MIN -3.5 vs. NYG
The key matchup in this game is WR Justin Jefferson and TE T.J. Hockenson vs. the Giants pass defense. Since moving from the slot to the perimeter in Week 3 of his 2020 rookie campaign for the Vikings, Jefferson has averaged 101.5 yards on 9.9 targets per game with an elite mark of 10.3 yards per target. He's No. 1 among all NFL wide receivers with 4,639 yards receiving in his first three seasons, and he's No. 1 in the league this year with 111 receptions overall and 64, 26, 14 and six receptions of 10-, 20-, 30- and 40-plus yards ( per our Advanced WR Stats Report). The Giants have been without No. 1 CB Adoree' Jackson (knee) since Week 11, and he didn't practice on Tuesday. I'm highly doubtful he plays, and without him the Giants don't have a corner who can hang with Jefferson. Similarly, the Giants are without S Xavier McKinney (hand, IR) – and they're No. 32 in defensive pass DVOA against tight ends (35.8%). Since joining the Vikings in Week 9, TE T.J. Hockenson is No. 2 on the team in targets (57), receptions (39) and yards receiving (335). Like Jefferson, Hockenson should be able to exploit the Giants pass defense. With this edge, the Vikings should be able to outscore the Giants by more than a field goal.
–