Here is our preview and best bet for the 2022 NFL Week 1 game between the Bills vs. Rams.
- NFL Week 1 Odds, Picks & Predictions: 49ers vs. Bears
- NFL Week 1 Odds, Picks & Predictions: Patriots vs. Dolphins
- NFL Week 1 Odds, Picks & Predictions: Browns vs. Panthers
- NFL Week 1 Odds, Picks & Predictions: Colts vs. Texans
- NFL Week 1 Odds, Picks & Predictions: Giants vs. Titans
- NFL Week 1 Odds, Picks & Predictions: Saints vs. Falcons
- NFL Week 1 Odds, Picks & Predictions: Steelers vs. Bengals
- NFL Week 1 Odds, Picks & Predictions: Eagles vs. Lions
- NFL Week 1 Odds, Picks & Predictions: Vikings vs. Packers
- NFL Week 1 Odds, Picks & Predictions: Raiders vs. Chargers
- NFL Week 1 Odds, Picks & Predictions: Ravens vs. Jets
Prop Bet Analyzer: View top rated props and historical prop performance by player >>
Buffalo is coming into the season as Super Bowl favorites and has the MVP favorite in Josh Allen. Von Miller will also be making his debut against his former team in the same place he won a championship with them. Jordan Poyer has returned to practice and should be able to play, but Tre'Davious White will not play. That should be a problem against one of the league's best passing offenses which averaged 11.4 yards per completion last season.