Here is our preview and best bet for the 2022 NFL Week 1 game between the 49ers vs. Bears.
- NFL Week 1 Odds, Picks & Predictions: Bills vs. Rams
- NFL Week 1 Odds, Picks & Predictions: Saints vs. Falcons
- NFL Week 1 Odds, Picks & Predictions: 49ers vs. Bears
- NFL Week 1 Odds, Picks & Predictions: Patriots vs. Dolphins
- NFL Week 1 Odds, Picks & Predictions: Browns vs. Panthers
- NFL Week 1 Odds, Picks & Predictions: Colts vs. Texans
- NFL Week 1 Odds, Picks & Predictions: Giants vs. Titans
- NFL Week 1 Odds, Picks & Predictions: Steelers vs. Bengals
- NFL Week 1 Odds, Picks & Predictions: Eagles vs. Lions
- NFL Week 1 Odds, Picks & Predictions: Vikings vs. Packers
- NFL Week 1 Odds, Picks & Predictions: Raiders vs. Chargers
- NFL Week 1 Odds, Picks & Predictions: Ravens vs. Jets
Prop Bet Analyzer: View top rated props and historical prop performance by player >>
This is a nightmare matchup for a Bears offensive line that ranked dead last in allowed sack rate in 2021. Nick Bosa and the rest of the 49ers pass rush that finished top 5 in sack rate should be living in the Chicago backfield all day. Justin Fields is capable of using his feet to make plays when the pocket breaks down, but the Bears got weaker at the pass-catching positions to bail him out.