The NFL kicks off Week 1 with 16 games to open up the 2022 regular season.
The defending champion Los Angeles Rams start it off listed as a 2.5-point home underdog against the Super Bowl-favorite Buffalo Bills, and it bookends with Russell Wilson returning back to Seattle with the Denver Broncos, who are 5-point road favorites in the Pacific Northwest.
When analyzing the full Week 1 schedule and lines, the first thing that pops out is the fact that 10 of the 16 home teams are listed as underdogs.
If Week 1 kicks off with 10 home underdogs, it would be the most such games in an opening week since the NFL moved to a 16-game schedule in 1978.
- Bills at Rams (+2.5)
- Ravens at Jets (+7)
- Saints at Falcons (+5)
- 49ers at Bears (+6.5)
- Eagles at Lions (+4.5)
- Colts at Texans (+8)
- Chiefs at Cardinals (+3)
- Packers at Vikings (+2)
- Buccaneers at Cowboys (+1.5)
- Broncos at Seahawks (+5)