Wild Card Weekend features two games with double-digit point spreads and two home underdogs. Here are our Wild Card Round upset picks.
The Jacksonville Jaguars are currently one-point underdogs against the Los Angeles Chargers, but they have seen all the support since opening at +2.5. The other AFC matchups feature big favorites taking on teams with unknown quarterback situations. Neither Tua Tagovailoa nor Lamar Jackson have been ruled in or out this weekend.
In the NFC, the Dallas Cowboys are road f avorites over the Tampa Bay Buccaneers, while the New York Giants are just three-point underdogs against the Minnesota Vikings. In the third game, the San Francisco 49ers are 10-point favorites over the Seattle Seahawks.
Here are our best NFL upset picks for Wild Card Weekend (odds via [FanDuel and Caesars sportsbooks]; pick confidence based on a 1-to-5-star scale).