Will the Tennessee Titans still prevail while shorthanded? Read why we're not so quick to write off the Titans as one of three underdogs we like for our Week 18 upset picks.
The Jacksonville Jaguars have won four straight while the Tennessee Titans have dropped six in a row, making Jacksonville a popular choice to win Saturday's showdown for the AFC South title.
Here are our top NFL upset picks for Week 18 (odds via FanDuel Sportsbook, PointsBet, and DraftKings Sportsbook; Picks based on a 1-to-5 star rating).
Check out our NFL against-the-spread pick power rankings for Week 18, and our odds and lines.
NFL Upset Picks for Week 18
- Titans (+240 via PointsBet) vs. Jaguars
- Panthers (+160 via FanDuel) vs. Saints
- Rams (+240 via DraftKings) vs. Seahawks