The NFL's annual Thanksgiving tripleheader opens Week 12 of the 2023 season and we're rounding up all of our betting experts' top NFL Thanksgiving predictions based on the odds from our best NFL betting sites.
The NFL's Thanksgiving tripleheader opens with the Green Bay Packers visiting the Detroit Lions for a 12:30 p.m. ET kickoff. The Dallas Cowboys and Washington Commanders will follow suit at 4:30 p.m. with the San Francisco 49ers' visit to play the rival Seattle Seahawks wrapping up the full day of football at 8:20 p.m. ET.
To help bridge the gap to the NFL's Sunday slate, we have our Dolphins vs. Jets predictions for the league's first-ever Black Friday game.
Check out our best NFL Thanksgiving predictions based on the top NFL Week 12 odds and betting lines.
NFL Thanksgivi ng schedule and odds
Odds via bet365 as of Tuesday at 10 a.m. ET
- Packers vs. Lions (-7.5), 12:30 p.m. ET, FOX
- Commanders vs. Cowboys (-11), 4:30 p.m. ET, CBS
- 49ers (-6.5) vs. Seahawks, 8:20 p.m. ET, NBC
NFL Thanksgiving predictions
Packers-Lions prediction made by Mike Spector.
Commanders-Cowboys prediction made by Phil Wood.
49ers-Seahawks prediction made by Brenden Schaeffer.
NFL expert picks for Thanksgiving
- Best bets
- Player props
- Parlay picks
- Anytime touchdown scorer predictions
NFL betting odds pages
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| NFL Defensive Player of the Year Odds | NFL Most Regular Season Rushing Yards Odds | NFL Draft Odds |
| NFL Coach of the Year Odds | NFL Most Regular Season Receiving Yards Odds |
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