The New England Patriots (1-2) will do their best to defy oddsmakers when they take on the San Francisco 49ers (1-2) on Sunday, September 29, 2024 as a 10.5-point underdog. The game’s point total is listed at 40.5.
Get game prop insights below in this article, including team to score first, first-half scoring props, and prop bets for the top players.
49ers vs. Patriots game odds
NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 7:41 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
- Spread: 49ers +10.5 (-105 to cover)
- Moneylines: 49ers -599, Patriots +425
- Total: 40.5 points (Over: -110, Under: -110)
- Pick ATS: 49ers (-10.5)
- Pick OU: Under (40.5)
- Prediction:
49ers 25 – Patriots 15