The Detroit Lions (1-1) are considered 3-point favorites heading into their matchup on Sunday, September 22, 2024 versus the Arizona Cardinals (1-1). For this game, the total has been set at 51.5 points.
Looking to make a parlay on this game? See insights, including team to score first, halftime score, and prop bets for the top players, int the article below.
Lions vs. Cardinals game odds
NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 7:41 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
- Spread: Lions +3 (-105 to cover)
- Moneylines: Lions -150, Cardinals +125
- Total: 51.5 points (Over: -110, Under: -110)
- Pick ATS: Cardinals (+3)
- Pick OU: Under (51.5)
- Prediction:
Cardinals 30 – Lions 19