The San Francisco 49ers (1-1) visit the Los Angeles Rams (0-2) on Sunday, September 22, 2024 in matchup between NFC West rivals at SoFi Stadium. The Rams are listed as 6.5-point underdogs. For this game, an over/under of 43.5 has been set.
Looking to place a parlay bet on this game? See insights, including first to score, first-half scoring props, and prop bets for the top players, below in this article.
49ers vs. Rams game odds
NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 7:41 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
- Spread: 49ers +6.5 (-115 to cover)
- Moneylines: 49ers -300, Rams +240
- Total: 43.5 points (Over: -110, Under: -110)
- Pick ATS: Rams (+6.5)
- Pick OU: Over (43.5)
- Prediction:
49ers 25 – Rams 22