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We're starting to see a clearer divide between contenders and pretenders as we offer our NFL Week 6 odds and predictions for the 14-game slate.
The Kansas City Chiefs remain the Super Bowl odds favorites as one of two undefeated teams, joining the surprise leader Minnesota Vikings in the NFC.
Both teams will be on a bye this week, though I'm targeting a few other contenders in my NFL Week 6 early picks.
Here's a look at the latest NFL Week 6 odds and our picks and predictions for every marquee game, which we'll update as kickoff approaches for each contest.
NFL picks & predictions Week 6
- 49ers vs. Seahawks early picks (TNF)
- 49ers vs. Seahawks prediction
- 49ers vs. Seahawks player props
- 49ers vs. Seahawks parlay
- Brocky Purdy player props
- Deebo Samuel player props
- First touchdown scorer predictions for TNF
- Anytime touchdown scorer predictions for TNF
- Jaguars vs. Bears early picks (London)
- Jaguars vs. Bears prediction
- Jaguars vs. Bears player props
- Jaguars vs. Bears parlay
- Caleb Williams player props
- Commanders vs. Ravens player props
- Jayden Daniels vs. Lamar Jackson player props
- Lions vs. Cowboys prediction
- Lions vs. Cowboys player props
- Bengals vs. Giants early picks (SNF)
- Bengals vs. Giants prediction
- Bengals vs. Giants player props
- Bengals vs. Giants parlay
- Joe Burrow player props
- Ja'Marr Chase vs. Malik Nabers player props
- First touchdown scorer predictions for SNF
- Anytime touchdown scorer predictions for SNF
- Bills vs. Jets early picks (MNF)
- Bills vs. Jets prediction
- Bills vs. Jets player props
- First touchdown scorer predic tions for MNF
- Anytime touchdown scorer predictions for MNF
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NFL odds for Thursday
NFL odds via bet365 and subject to change. Follow the latest NFL scores for line history and matchup info.
- When: Thursday, Oct. 10 – 8:15 p.m. ET
- Where: Lumen Field (Seattle)
- How to watch: Amazon Prime Video
- Moneyline: 49ers -180 | Seahawks +150
- Spread: 49ers -3 (-120) | Seahawks +3 (+100)
- Total: 47.5 (-110/-110)
NFL odds for Sunday
- When: Sunday, Oct. 13 – 9:30 a.m. ET
- Where: Tottenham Hotspur Stadium (London)
- How to watch: NFL Network
- Moneyline: Jaguars +110 | Bears -130
- Spread: Jaguars +2 (-110) | Bears -2 (-110)
- Total: 44.5 (-110/-110)
- When: Sunday, Oct. 13 – 1 p.m. ET
- Where: Caesars Superdome (New Orleans)
- How to watch: FOX
- Mon eyline: Buccaneers -130 | Saints +110
- Spread: Buccaneers -1.5 (-115) | Saints +1.5 (-105)
- Total: 43.5 (-110/-110)
- When: Sunday, Oct. 13 – 1 p.m. ET
- Where: Lambeau Field (Green Bay, Wisc.)
- How to watch: FOX
- Moneyline: Cardinals +200 | Packers -245
- Spread: Cardinals +5 (-110) | Packers -5 (-110)
- Total: 49.5 (-110/-110)
- When: Sunday, Oct. 13 – 1 p.m. ET
- Where: Lincoln Financial Field (Philadelphia)
- How to watch: FOX
- Moneyline: Browns +350 | Eagles -450
- Spread: Browns +8.5 (-110) | Eagles -8.5 (-110)
- Total: 43 (-110/-110)
- When: Sunday, Oct. 13 – 1 p.m. ET
- Where: Gillette Stadium (Foxborough, Mass.)
- How to watch: CBS
- Moneyline: Texans -300 | Patriots +240
- Spread: Texans -7 (-10 5) | Patriots +7 (-115)
- Total: 37.5 (-110/-110)
- When: Sunday, Oct. 13 – 1 p.m. ET
- Where: M&T Bank Stadium (Baltimore, Md.)
- How to watch: CBS
- Moneyline: Commanders +235 | Ravens -290
- Spread: Commanders +6.5 (-110) | Ravens -6.5 (-110)
- Total: 52.5 (-110/-110)
- When: Sunday, Oct. 13 – 1 p.m. ET
- Where: Nissan Stadium (Nashville)
- How to watch: CBS
- Moneyline: Colts -115 | Titans -105
- Spread: Colts -1 (-110) | Titans +1 (-110)
- Total: 43 (-110/-110)
- When: Sunday, Oct. 13 – 4:05 p.m. ET
- Where: Allegiant Stadium (Las Vegas)
- How to watch: CBS
- Moneyline: Steelers -155 | Raiders +130
- Spread: Steelers -3 (-105) | Raiders +3 (-115)
- Total: 36.5 (-110/-110)
- When: Sun day, Oct. 13 – 4:05 p.m. ET
- Where: Empower Field at Mile High (Denver)
- How to watch: CBS
- Moneyline: Chargers -160 | Broncos +135
- Spread: Chargers -3 (-110) | Broncos +3 (-110)
- Total: 35.5 (-110/-110)
- When: Sunday, Oct. 13 – 4:25 p.m. ET
- Where: Bank of America Stadium (Charlotte)
- How to watch: FOX
- Moneyline: Falcons -270 | Panthers +220
- Spread: Falcons -6 (-110) | Panthers +6 (-110)
- Total: 47.5 (-110/-110)
- When: Sunday, Oct. 13 – 4:25 p.m. ET
- Where: AT&T Stadium (Arlington, Texas)
- How to watch: FOX
- Moneyline: Lions -170 | Cowboys +145
- Spread: Lions -3.5 (+100) | Cowboys +3.5 (-120)
- Total: 52.5 (-110/-110)
- When: Sunday, Oct. 13 – 8:20 p.m. ET
- Where: MetLife Stadium (East Rutherford, N.J.)
- How to watch: NBC
- Moneyline: Bengals -180 | Giants +150
- Spread: Bengals -3.5 (+100) | Giants +3.5 (-120)
- Total: 48.5 (-110/-110)
NFL odds for Monday
- When: Monday, Oct. 14 – 8:15 p.m. ET
- Where: MetL ife Stadium (East Rutherford, N.J.)
- How to watch: ESPN
- Moneyline: Bills -140 | Jets +120
- Spread: Bills -2.5 (-110) | Jets +2.5 (-110)
- Total: 41 (-110/-110)
NFL picks roundup: Week 6
- NFL Week 6 early picks & predictions
- NFL Week 6 against the spread
- NFL upset picks Week 6
- NFL predictions & best bets Week 6
- Anytime touchdown scorer predictions
- Touchdown parlay Week 6
- NFL player props Week 6
NFL betting odds pages
| Super Bowl Odds | NFL MVP Odds | NFL Offensive Player of the Year Odds |
| NFL Defensive Player of the Year Odds | NFL Offensive Rookie of the Year Odds | NFL Defensive Rookie of the Year Odds |
| NFL Coach of the Year Odds | NFL Comeback Player of the Year Odds | NFL Win Totals Odds |
| NFL Playoff Odds | NFL Draft Odds |
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