Real-world results are becoming more and more significant as we round up all of our NFL predictions for Week 3 based on the odds from our best NFL betting sites.
There's a canyon-sized difference between an 0-2 start and 0-3 in the NFL. Similarly, getting to 3-0 can push aside doubts surrounding a 2-0 record. In Week 3, nine teams are looking to get to 3-0 while another nine are at risk of falling to that 0-3 mark.
Week 3 starts with what's expected to be a lopsided matchup between the host San Francisco 49ers and the New York Giants on Thursday Night Football. Our second-to-last full slate of games before byes start in Week 5 will conclude with another Monday Night Football doubleheader with the Philadelphia Eagles visiting the Tampa Bay Buccaneers and Los Angeles Rams traveling to face the Cincinnati Bengals.
Here are our betting experts' best predict ions for all 16 games this week based on the NFL Week 3 odds.
NFL picks and predictions for Week 3
- Giants vs. 49ers prediction
- Titans vs. Browns prediction
- Falcons vs. Lions prediction
- Saints vs. Packers prediction
- Broncos vs. Dolphins prediction
- Chargers vs. Vikings prediction
- Patriots vs. Jets prediction
- Bills vs. Commanders prediction
- Texans vs. Jaguars prediction
- Colts vs. Ravens prediction
- Panthers vs. Seahawks prediction
- Bears vs. Chiefs prediction
- Cowboys vs. Cardinals prediction
- Steelers vs. Raiders prediction
- Eagles vs. Buccaneers prediction
- Rams vs. Bengals prediction
NFL Week 3 predictions: Thursday
Giants-49ers pick made by Mike Spector
NFL Week 3 predictions: Sunday
NFL Week 3 predictions: Monday
NFL Week 3 expert picks
- Best bets
- Player props
- Survivor picks
- Upset picks
- Touchdown props
- Teaser picks
- Parlay picks
- NFL expert ATS picks
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NFL betting odds pages
| Super Bowl Odds | NFL Defensive Rookie of the Year Odds | NFL Sacks Leader Odds |
| NFL MVP Odds | NFL Comeback Player of the Year Odds | NFL Best Record Odds |
| NFL Offensive Player of the Year Odds | NFL Most Regular Season Passing Yards Odds | NFL Worst Record Odds |
| NFL Defensive Player of the Year Odds | NFL Most Regular Season Rushing Yards Odds | NFL Win Totals Odds |
| NFL Coach of the Year Odds | NFL Most Regular Season Receiving Yards Odds | NFL Draft Odds |
| NFL Offensive Rookie of the Year Odds |
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- DraftKings Promo Code | Read our DraftKings Review
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Related pages
- Best Sports Betting Sites | Best Sportsbook Promos (U.S. only)