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The Thursday Night Football matchup between the Buffalo Bills and Miami Dolphins, two Super Bowl odds contenders, was a great way to kick off Week 2, and now we shift our focus to the weekend.
After Week 1, in which 11 of the 16 games had spreads of 3.5 points or lower, six of the remaining 15 games for Week 2 have spreads in that same range. That speaks to the parity around the league.
It would not be an NFL season without injuries, and a team that was decimated by injuries in Week 1 is one we're fading with with one of our two game picks this week.
Last week's NFL best bets went 3-1, including cashes on each of our game picks, so we will look to replicate that success as look ahead to all of our NFL Week 2 predictions.
Best NFL bets for Week 2
NFL odds as of Friday and subject to change. Track the NFL scores for the latest line movement and matchup info.
- Derrick Henry to score 2+ touchdowns (+330 via FanDuel) vs. Raiders ???
- Jayden Daniels Over 17.5 completions (-120 via FanDuel) vs. Giants ????
- Buccaneers-Lions Over 51 (-112 via DraftKings) ????
- Cardinals -1 (-110 via Caesars) vs. Rams ????
Week 2 NFL odds & schedule
(Odds via BetMGM)
- Tampa Bay Buccaneers (+7.5) vs. Detroit Lions (-7.5), Sunday at 1 p.m. ET
- Los Angeles Chargers (-6) vs. Carolina Panthers (-6), Sunday at 1 p.m. ET
- Indianapolis Colts (-2.5) vs. Green Bay Packers (+2.5), Sunday at 1 p.m. ET
- San Francisco 49ers (-5.5) vs. Minnesota Vikings (+5.5), Sunday at 1 p.m. ET
- Cleveland Browns (+3) vs. Jacksonville Jaguars (-3), Sunday at 1 p.m. ET
- New York Jets (-4) vs. Tennessee Titans (+4), Sunday at 1 p.m. ET
- Las Vegas Raiders (+8.5) vs. Baltimore Ravens (-8.5), Sunday at 1 p.m. ET
- New York Giants (+1.5) vs. Washington Commanders (-1.5), Sunday at 1 p.m. ET
- New Orleans Saints (+6.5) vs. Dallas Cowboys (-6.5), Sunday at 1 p.m. ET
- Seattle Seahawks (-3) vs. New England Patriots (+3), Sunday at 1 p.m. ET
- Los Angeles Rams (+1.5) vs. Arizona Cardinals (-1.5), Sunday at 4:05 p.m. ET
- Pittsburgh Steelers (-2.5) vs. Denver Broncos (+2.5), Sunday at 4:25 p.m. ET
- Cincinnati Bengals (+5.5) vs. Kansas City Chiefs (-5.5), Sunday at 4:25 p.m. ET
- Chicago Bears (+6.5) vs. Houston Texans (-6.5), Sunday at 8:20 p.m. ET
- Atlanta Falcons (+7) vs. Philadelphia Eagles (-7), Monday at 8:15 p.m. ET
NFL player props for Week 2
NFL picks made Friday; odds subject to change. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!
The Las Vegas Raiders allowed 176 rushing yards to the Los Angeles Chargers, which was L.A.'s highest rushing total in nearly a calendar year (362 days). That's a bad recipe when facing the run-heavy Baltimore Ravens, who ran for 185 yards and 5.8 yards per carry in Week 1.
The Ravens' coaching staff knows that letting Lamar Jackson run 16 times per game isn't sustainable for his health, so I expect Derrick Henry to record more than the 13 carries he was given last week.
Henry has double-digit rushing touchdowns in six consecutive seasons, and a good sign for success in this matchup is that J.K. Dobbins ran for the second and third-longest runs of his career last week.
Henry's anytime touchdown odds are as short as -200 (carrying a 66.67% implied probability) at our best sports betting sites, making these +330 odds at FanDuel for him to cross the goal line twice a great value.
Caesars offers odds of +210 for Henry to score two-plus touchdowns. At FanDuel, a winning $10 wager would return $33 in profits.
Best odds: +330 via FanDuel | Implied probability: 23.26%
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Jayden Daniels showed what he can do with his legs in Week 1, becoming the first quarterback in NFL history with 80-plus rushing yards and two or more rushing touchdowns in their NFL debut.
However, now he has to show his arm talent, and he faces a New York Giants defense that was shredded by Sam Darnold last week.
From 2018 to 2023, Darnold averaged a 42 total QBR of 42, completed 60% of his passes, and averaged 6.7 yards per attempt. Last week, Darnold posted an 81 total QBR with a 79% completion percentage (the second-best of his career as a starter), and completed 13 of 14 passes in the first half alone.
This line is juiced as high as -140 (carrying a 58.33% implied probability) at BetMGM, while Caesars has a different number altogether with an O/U of 18.5 completions.
Thus, the combination of the best price and number is at FanDuel, with a winning $10 wager paying out $18.33.
Best odds: -120 via FanDuel | Implied probability: 54.55%
NFL game predictions for Week 2
For the second consecutive week, the Detroit Lions play a home game against a team they beat at home in the playoffs last year.
Though their Week 1 tilt with the Los Angeles Rams stayed Under the 53.5 total, just as it did in last year's playoff meeting, I expect a high-scoring game against the Tampa Bay Buccaneers, just like their divisional-round meeting that ended 31-23 last year.
Detroit's offense the last two seasons under offensive coordinator Ben Johnson has ranked first in yards per game, third in scoring, third in yards per play, and its quarterbacks have ranked fifth in total QBR.
The Lions' offense looks even scarier with Jameson Williams living up to the hype, with a 121-yard receiving day in Week 1.
Meanwhile, Baker Mayfield is coming off his fifth career game with four-plus touchdown passes, following a season in which he posted career-highs in completion percentage, passing yards, and passing touchdowns.
This total is up at least two points at all of our best sports betting apps this week from an opening number of 49, but DraftKings is the only sportsbook that has not gone to 51.5 yet, making it my preferred shop.
A $10 winning wager would pay out $18.93.
Best odds: -112 via DraftKingss | Implied probability: 52.83%
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The Arizona Cardinals lost valiantly 34-28 on the road against the Buffalo Bills and at one point held a two-touchdown lead with less than a minute to play in the first half.
Arizona showed its offensive versatility, running for 5.0 yards per carry and completing passes to eight different receivers. Plus, the 28 points scored were impressive considering rookie wide receiver Marvin Harrison Jr. had just one catch for four yards.
Arizona is just 2-13 in its last 15 games against the Rams and has lost 14 of its last 15 overall against NFC West opponents. However, Puka Nacua's knee injury makes L.A.'s offense that much less explosive, and Kyler Murray has averaged 305.3 passing yards per game in his last four starts against the Rams.
In addition, Los Angeles's offensive line is decimated by injuries, as tackle Joe Noteboom (ankle) and guard Steve Avila (knee) are expected to miss multiple weeks. The Rams could be without four starters on the offensive line, which is a big reason the line jumped the fence this week from Rams -1.5.
I would have played the Cardinals on the moneyline as underdogs even without the line movement, and I certainly do not mind laying the one-point at Caesars – three of our other best sportsbooks are a half-point higher at Cardinals -1.5).
A $10 winning wager would return $9.09 in profits.
Best odds: -110 via Caesars | Implied probability: 52.38%
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