NFL odds, Week 5: Where point spreads sit ahead of the first injury reports

The NFL is headed back to practice. Wednesday marks the start of practice for all the Sunday games and that is when we start to get a better handle on who is good to go, who is a little banged up, and who is a decent bet to not play on Sunday.

The first practice participation reports will start showing up later in the morning, but before then, we've got an updated look at where odds sit at DraftKings Sportsbook. Each game shows odds that were released in May, where they re-opened with the lookahead line last week, where they re-opened again on Sunday night, and where they sit three days later.

The biggest moves this week are 49ers-Panthers and Cowboys-Rams. The 49ers opened Sunday night as a four-point favorite, but their strong win over the Rams on has resulted in this line moving to six points. Meanwhile, the Cowboys opened Sunday night as a six-point underdog, but that line has now moved to 4.5 points. The most notable part of that game is Dak Prescott's uncertain status, so we'll keep an eye on the injury report for his participation.

Colts vs. Broncos

Point spread: Broncos -3.5
Point total: 42.5
Moneyline: Broncos -170, Colts +145

Point spread: Broncos -3
Point total: 43
Moneyline: Broncos -165, Colts +140

Point spread: Broncos -2.5
Point total: 43
Moneyline: Broncos -140, Colts +120

Opening point spread: Broncos -3
Opening moneyline: Broncos -155, Colts +135

Giants vs. Packers

Point spread: Packers -8.5
Point total: 41
Moneyline: Packers -360, Giants +295

Point spread: Packers -7.5
Point total: 41
Moneyline: Packers -340, Giants +280

Point spread: Packers -7.5
Point total: 41
Moneyline: Packers -340, Giants +280

Opening point spread: Packers -6.5
Opening moneyline: Packers -280, Giants +225

Steelers vs. Bills

Point spread: Bills -14
Point total: 47
Moneyline: Bills -950, Steelers +650

Point spread: Bills -14
Point total: 47
Moneyline: Bills -950, Steelers +650

Point spread: Bills -13
Point total: 47.5
Moneyline: Bills -800, Steelers +575

Opening point spread: Bills -8
Opening moneyline: Bills -425, Steelers +320

Chargers vs. Browns

Point spread: Chargers -3
Point total: 47.5
Moneyline: Chargers -155, Browns +135

Point spread: Chargers -3
Point total: 48
Moneyline: Chargers -155, Browns +135

Point spread: Chargers -1.5
Point total: 48
Moneyline: Chargers -125, Browns +105

Opening point spread: N/A
Opening moneyline: N/A

Bears vs. Vikings

Point spread: Vikings -7
Point total: 44
Moneyline: Vikings -320, Bears +265

Point spread: Vikings -7
Point total: 43
Moneyline: Vikings -320, Bears +265

Point spread: Vikings -6.5
Point total: 43
Moneyline: Vikings -275, Bears +230

Opening point spread: Vikings -4.5
Opening moneyline: Vikings -195, Bears +165

Lions vs. Patriots

Point spread: Patriots -3
Point total: 46.5
Moneyline: Patriots -155, Lions +135

Point spread: Patriots -2.5
Point total: 47
Moneyline: Patriots -140, Lions +120

Point spread: Pick 'em
Point total: 44
Moneyline: Patriots -110, Lions -110

Opening point spread: Patriots -5
Opening moneyline: Patriots -235, Lions +190

Seahawks vs. Saints

Point spread: Saints -5.5
Point total: 46
Moneyline: Saints -225, Seahawks +190

Point spread: Saints -5
Point total: 42.5
Moneyline: Saints -215, Seahawks +185

Point spread: Saints -6
Point total: 41
Moneyline: Saints -250, Seahawks +210

Opening point spread: Saints -4.5
Opening moneyline: Saints -195, Seahawks +165

Dolphins vs. Jets

Point spread: Dolphins -3
Point total: 44
Moneyline: Dolphins -175, Jets +150

Point spread: Dolphins -3
Point total: 43.5
Moneyline: Dolphins -155, Jets +135

Point spread: Dolphins -5.5
Point total: N/A
Moneyline: Dolphins -245, Jets +205

Opening point spread: Dolphins -2.5
Opening moneyline: Dolphins -145, Jets +125

Falcons vs. Bucs

Point spread: Bucs -9
Point total: 48
Moneyline: Bucs -410, Falcons +330

Point spread: Bucs -8.5
Point total: 47.5
Moneyline: Bucs -380, Falcons +310

Point spread: Bucs -9
Point total: 47.5
Moneyline: Bucs -410, Falcons +330

Opening point spread: Bucs -10.5
Opening moneyline: Bucs -630, Falcons +450

Titans vs. Commanders

Point spread: Titans -2.5
Point total: 42.5
Moneyline: Titans -140, Commanders +120

Point spread: Titans -2.5
Point total: 42.5
Moneyline: Titans -140, Commanders +120

Point spread: Pick 'em
Point total: 42.5
Moneyline: Titans -110, Commanders -110

Opening point spread: Pick 'em
Opening moneyline: Titans -110, Commanders -110

Texans vs. Jaguars

Point spread: Jaguars -7
Point total: 44
Moneyline: Jaguars -330, Texans +275

Point spread: Jaguars -7
Point total: 44
Moneyline: Jaguars -320, Texans +265

Point spread: Jaguars -7
Point total: 43.5
Moneyline: Jaguars -295, Texans +245

Opening point spread: Jaguars -3
Opening moneyline: Jaguars -155, Texans +135

49ers vs. Panthers

Point spread: 49ers -6.5
Point total: 38.5
Moneyline: 49ers -275, Panthers +230

Point spread: 49ers -4
Point total: 39
Moneyline: 49ers -190, Panthers +160

Point spread: 49ers -3
Point total: 39
Moneyline: 49ers -165, Panthers +140

Opening point spread: 49ers -3
Opening moneyline: 49ers -160, Panthers +140

Cowboys vs. Rams

Point spread: Rams -4.5
Point total: 43
Moneyline: Rams -205, Cowboys +175

Point spread: Rams -6
Point total: 45.5
Moneyline: Rams -245, Cowboys +205

Point spread: Rams -7
Point total: 46
Moneyline: Rams -300, Cowboys +250

Opening point spread: Rams -4.5
Opening moneyline: Rams -190, Cowboys +160

Eagles vs. Cardinals

Point spread: Eagles -5.5
Point total: 49
Moneyline: Eagles -225, Cardinals +190

Point spread: Eagles -6
Point total: 49.5
Moneyline: Eagles -240, Cardinals +200

Point spread: Eagles -4
Point total: 48.5
Moneyline: Eagles -195, Cardinals +165

Opening point spread: Cardinals -2
Opening moneyline: Cardinals -130, Eagles +110

Bengals vs. Ravens

Point spread: Ravens -3
Point total: 48.5
Moneyline: Ravens -170, Bengals +145

Point spread: Ravens -3
Point total: 48.5
Moneyline: Ravens -175, Bengals +150

Point spread: Bengals -3
Point total: N/A
Moneyline: Bengals -165, Ravens +140

Opening point spread: Ravens -1
Opening moneyline: Ravens -120, Bengals +100

Raiders vs. Chiefs

Point spread: Chiefs -7
Point total: 51
Moneyline: Chiefs -325, Raiders +270

Point spread: Chiefs -6.5
Point total: 50.5
Moneyline: Chiefs -320, Raiders +265

Point spread: Chiefs -6.5
Point total: 50.5
Moneyline: Chiefs -295, Raiders +245

Opening point spread: Chiefs -4.5
Opening moneyline: Chiefs -195, Raiders +165

  
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