There’s no shortage of explosive offenses in the NFL this season, and they should be considered for some of the highest scoring totals on any given week.
Whether you’re looking at Josh Allen and the Buffalo Bills or Aaron Rodgers and the Green Bay Packers, high totals will undoubtedly be prevalent this year when it comes to NFL betting, especially in a division like the AFC West.
NFL Odds Week 1: Biggest Over Under Totals This Week
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| Rank | Matchup | Total |
|---|---|---|
| 1 | Kansas City Chiefs vs. Arizona Cardinals | 53.5 |
| T2 | Buffalo Bills vs. Los Angeles Rams | 52.5 |
| T2 | Las Vegas Raiders vs. Los Angeles Chargers | 52.5 |
| 4 | Tampa Bay Buccaneers vs. Dallas Cowboys | 50.5 |
| T5 | Philadelphia Eagles vs. Detroit Lions | 48.5 |
| T5 | Green Bay Packers vs. Minnesota Vikings | 48.5 |
| 7 | New England Patriots vs. Miami Dolphins | 46.5 |
| 8 | Indianapolis Colts vs. Houston Texas | 45.5 |
| T9 | Baltimore Ravens vs. New York Jets | 44.5 |
| T9 | Pittsburgh Steelers vs. Cincinnati Bengals | 44.5 |
1. Kansas City Chiefs vs. Arizona Cardinals (Total: 53.5)
In what’s projected to be the highest scoring game of Week 1, Patrick Mahomes and the Kansas City Chiefs will visit Kyler Murray and the Arizona Cardinals, which currently has a lofty total of 53.5.
2. (Tie) Buffalo Bills vs. Los Angeles Rams (Total: 52.5)
Kicking off the 2022 NFL season, the defending Super Bowl champion Los Angeles Rams will host Josh Allen and the Buffalo Bills. Both offenses should again be explosive, represented by the total set at 52.5.