Week 1 of the NFL season has finally arrived and when looking at the NFL odds for this week, there aren’t as many big spreads as you might think.
NFL Odds Week 1: Biggest NFL Spreads This Week
table_builder($table) –>
| Rank | Matchup | Spread |
|---|---|---|
| 1 | Indianapolis Colts vs. Houston Texans | Colts -8.5 |
| T2 | Baltimore Ravens vs. New York Jets | Ravens -7 |
| T2 | San Francisco 49ers vs. Chicago Bears | 49ers -7 |
| T4 | Pittsburgh Steelers vs. Cincinnati Bengals | Bengals -6.5 |
| T4 | Denver Broncos vs. Seattle Seahawks | Broncos -6.5 |
| 6 | New York Giants vs. Tennessee Titans | Titans -6 |
| 7 | New Orleans Saints vs. Atlanta Falcons | Saints -5.5 |
| 8 | Kansas City Chiefs vs. Arizona Cardinals | Chiefs -4.5 |
| 9 | Philadelphia Eagles vs. Detroit Lions | Eagles -4 |
| 10 | Las Vegas Raiders vs. Los Angeles Chargers | Chargers -3.5 |
1. Indianapolis Colts (-8.5) vs. Houston Texans
Maybe a surprising number here for some, but the Indianapolis Colts have an offense that should be explosive, led by Jonathan Taylor at running back. The Houston Texans should be improved, but this spread says a lot about how oddsmakers view them.
2. (Tie) Baltimore Ravens (-7) vs. New York Jets
After missing the playoffs in 2021, the Baltimore Ravens are back and poised to be a force in the AFC North, leaving them as a touchdown-sized road favorite in their Week 1 opener against the New York Jets.
2. (Tie) San Francisco 49ers (-7) vs. Chicago Bears
Trey Lance will kick off the season as the QB1 for the San Francisco 49ers, but how long is the leash for the second-year pro after a lackluster preseason? With that, the 49ers are still favored by a touchdown in their opening matchup against the lowly Chicago Bears.