The opening Sunday of the 2023 NFL season is nearly here, and there's an appetizing slate for Sep. 10. Two historic franchises clash in Steelers vs. 49ers at 1 p.m. ET, while a rematch of a recent Super Bowl takes place at 4:25 p.m. ET in Eagles vs. Patriots. The Niners are 2.5-point favorites in the latest Week 1 NFL odds, while Philly is a 4.5-point road favorite over New England. Elsewhere, the Ravens are the biggest favorites of the Week 1 NFL schedule as they are giving 10 points versus the Texans.
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