NFL DFS Picks for 49ers vs Cardinals Monday night

NFL Week 11 DFS continues with a classic NFC West battle between the San Francisco 49ers and Arizona Cardinals in Mexico City. This marks the fifth and final international installment of the 2022 NFL season and there are a lot of outside factors in play. First off, we have the altitude, which thins the air and can make it tougher on the players if they aren't prepared. We also have thunderstorms in the forecast, so this game could even get a little sloppy. On top of that, we also won't know until much closer to game time if Kyler M urray will be under center for Arizona.

As a result, building NFL DFS Showdown lineups could get a little complicated, so make sure you have a few options and pivots set up for some last-minute changes. Follow both the NFL injury and weather reports to make sure you are completely in tune with what is going on and our player recommendations should take care of the rest.

Please note that players not listed below are not necessarily a complete fade and any player listed could certainly be used as the MVP/Captain. These are merely suggestions for players to use when setting showdown lineups.

 

MVP/Captain

Christian McCaffrey, 49ers running back

Christian McCaffrey is a pretty obvious choice for the top spot in your lineup as there are numerous things working in his favor. The Cardinals may only allow an average of 110.5 rushing yards per game, but they've given up 12 rushing touchdowns on the year. In addition to that, Arizona ranks 30th in DVOA against running back pass plays and allow the 12th-most fantasy points per game to the running back position.

George Kittle, 49ers tight end

While most lean on the 49ers’ ground game, you don't want to sleep on Kittle as the Cardinals rank 31st in DVOA against the tight end and also allow the most fantasy points per game to the position. Heading into the Week 9 bye, Kittle had back-to-back games with a touchdown, so while he saw only 2 targets last week, he should be more actively involved this week.

Kyler Murray/Colt McCoy, Cardinals quarterback

  
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