NFL Computer Picks, Analysis and Best Bet For 49ers vs. Broncos on September 25, 2022
NFL Computer Picks, Analysis and Best Bet For 49ers vs. Broncos on September 25, 2022

The Denver Broncos haven't looked great to start the season, but they can gain some momentum by knocking off the San Francisco 49ers in Denver on Sunday, September 25 at 8:20PM ET. Russell Wilson and the 49ers defense will be very familiar with one another from the star quarterback's time in Seattle. That should ultimately make this a fun chess match between the two teams. 

Find out how we think this one will play out in our 49ers vs. Broncos betting preview below. 

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49ers vs. Broncos Computer Picks

  • 56% chance the 49ers win on the money line
  • 52% probability the 49ers cover the -1 spread
  • 52% chance 49ers vs. Broncos goes Under 45 total points

For the best NFL computer picks, check out our Packers vs. Buccaneers data predictions. They are constantly updating based on hundreds of different data points.

 

49ers vs. Broncos Analysis

  
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By Dimers