Welcome to the Pickswise NFL Week 1 betting guide. The nation’s favorite sport is back in full force on Sunday with 28 teams playing for the first time this season — and there are some great revenge games on a sizzling slate with the Browns facing new Panthers QB Baker Mayfield and Russell Wilson returning to his former team Seattle with the Broncos.
Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your best on the first NFL Sunday slate of the season (and Monday Night Football too!).
Don’t forget to check out our great new game previews, which now include prop picks, projections, trends and same game parlays!
Pickswise NFL Preview 2022
There’s still time to read the Pickswise NFL Preview, which includes full previews of all 32 teams, all our experts’ futures picks for the year and much more. You can find our FREE NFL preview here, presented by Superbook Sports.