NFL Week 4 is upon us and so far we’ve seen a ton of upsets already this season. Last week, the 49ers got downed by a depleted Rams team, while the Vikings dominated the Texans. On top of that, we saw a shootout for the ages as the Commanders beat the Bengals 38-33 on primetime football. So, what does Week 4 have in store? We already saw the Cowboys squeak past the Giants on TNF, but we have a ton more exciting action to sink our teeth into. Let’s get into the action with our Pickswise experts’ 3-star NFL best bets for Week 4, while you can also find out our NFL picks on the side and total for EVERY matchup this season.
NFL Week 4 best bet: Jaguars +6.5 over Texans (-112)
We have a crucial AFC South matchup on our hands with our Jaguars vs Texans prediction and both teams are out to bounce back from crushing defeats in Week 3. The Texans were decimated 34-7 by the Vikings on Sunday before the Jaguars were humiliated 47-10 by the Bills. Having been 4.5-point underdogs on Monday morning, that annihilation in Buffalo has now pushed Jacksonville out by another 2 points and I believe it's worth jumping on them now that public perception is so low.
I won't sugarcoat it – the Jags looked awful in that game in Buffalo. Trevor Lawrence has completed barely 50% of his passes this season while the defense was schooled by Josh Allen. However, I'm expecting this team to come out firing in a big divisional game where they know that a win here will suddenly put them 1 win out of first place in the AFC South. This defense has what it takes to slow down opposing offenses, as we saw them do against the Dolphins and Browns, and has allowed the 8th-fewest yards per carry.