Led by head coach Deion Sanders and surprise Heisman Trophy candidates Travis Hunter and Shedeur Sanders, the Colorado Buffaloes enter Week 2 of the college football season ranked in the top-25 for the first time since the 2020 season. No. 22 CU will face longtime rival Nebraska in the first home game of the Coach Prime era. Kickoff at Folsom Field in Boulder, Colo. is set for 12 p.m. ET. Colorado is coming off a massive 45-42 upset over TCU in its season opener. The Cornhuskers are looking to bounce back from a 13-10 season opening loss to Minnesota in their first game under new head coach Matt Rhule. The Buffs are 3-point favorites in the latest Colorado vs. Nebraska odds, while the over/under for total points scored is set at 59.5 (see up-to-date'odds for every game this week on our college football odds page).
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