MLB odds, lines, picks: Advanced computer model includes the Diamondbacks in parlay for Sept. 16 that would pay almost 33-1

Houston Astros ace and American League Cy Young favorite Justin Verlander returns to the mound for the first time since Aug. 28 when he faces the Oakland A's in the second game of a four-game series on Friday at Minute Maid Park in Houston. The 39-year-old Verlander (16-3, 1.84 ERA) has missed three starts with a minor calf issue. He leads the majors in ERA and WHIP (0.86) and is tied for second in wins.

Houston is a -385 favorite in the latest Astros vs. A's odds from Caesars Spo rtsbook, while Oakland is a +300 underdog. The over/under for runs scored is 7.5. First pitch is set for 8:10 p.m. ET. The game is one of 15 on the MLB schedule for Friday. (See up-to-date'lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 316-272 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win the World Series. Anybody who has followed it has seen profitable returns.

  
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