Red Sox lefty Chris Sale makes his 2022 debut when he takes the mound on Tuesday against the Tampa Bay Rays at Tropicana Field in St. Petersburg, Fla. A seven-time All-Star, Sale has missed the first half of the season with a fracture in his right rib cage. He will square off against Corey Kluber in the second game of the four-game series.
Boston is a -115 favorite in the latest Red Sox vs. Rays odds from Caesars Sportsbook while Tampa Bay is a -105 underdog. First pitch is set for 7:10 p.m. ET . The game is one of 16 on the MLB schedule for Tuesday. (See up-to-date'lines for every game on our MLB odds page.)
Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.
The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 275-236 on top-rated MLB money-line picks since the start of the 2021 season, returning more than $400 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win the World Series. Anybody who has followed the model has seen profitable returns.