The NCAA Tournament Round of 32 starts on Saturday, and we're looking at our March Madness upset predictions based on the best March Madness odds.
We've already seen some of our March Madness upset picks come true through the first round of the NCAA Tournament. We could be in store for even more chaos in the second start, which begins Saturday with eight matchups on deck.
Thursday featured four double-digit seeds advancing over higher-seeded teams, leading to a Saturday schedule with one 11 vs. 14 matchup and two 3 vs. 11 matchups. Can all three 11 seeds advance to the Sweet 16?
The North Carolina Tar Heels face a formidable challenge in the second round as they take on the Michigan State Spartans. Also, one of the three No. 2 seeds playing on Saturday is in danger of being upset.
To help with your March Madness bracket, here are our best March Madness upset predictions for Saturday (odds via our best March Madness betting sites; pick confidence based on a 1-to-5-star scale).
Saturday's top NCAA Tournament upset predictions
- Dayton (7) vs. Arizona (2) (+375 via bet365) ??
- Michigan State (9) vs. North Carolina (1) (+155 via BetMGM) ????
- Oregon (11) vs. Creighton (3) (+220 via BetMGM) ???
Not intended for use in MA
Affiliate Disclosure: Sportsbook Review may receive advertising commissions for visits to a sportsbook
Best odds: +375 via bet365
Game info: Saturday at 12:45 p.m. ET at Delta Center, Salt Lake City, Utah
bet365 promo
Get a 32% boost on any SGP for Round 2 through bet365 on Saturday. Don't forget to use our bet365 bonus code! Offer excludes Ontario.
In Round 1, the Dayton Flyers trailed 56-39 with 7:36 remaining. They ended up winning the game 63-60. Though many will look at that performance and call it flukey, it may be just what the Flyers needed to spring an upset over the Arizona Wildcats in Round 2.
The Wildcats used a huge second half to pull away from Long Beach State. However, they were outrebounded in that game, which could be problematic against Daron Holmes II and the Flyers.
Additionally, the Wildcats used 13 threes to get the win. The Flyers rank 52nd in the country in opponent 3-point percentage, so it's unlikely the Wildcats hit that number again.
The Wildcats average 87.9 points per game. If the Flyers can make the Wildcats play their tempo, then this is going to be close late.
Dayton has already proven it can win that type of game in the tournament, and at +350 or better with our best sports betting sites, the Flyers are worth a play to win outright.
Best odds: +155 via BetMGM
Game info: Saturday at 5:30 p.m. ET, at Spectrum Center, Charlotte, NC
The Spartans dominated the Mississippi State Bulldogs in their 69-51 Round 1 win. They shot 50% from the floor and 43.5% from 3-point range, and they held the Bulldogs to 37.0% from the floor and 22.2% from deep.
The Tar Heels may have an edge on the glass in this game, but the Spartans likely hold the advantage everywhere else. The Tar Heels are an offensive-minded team, but the Spartans can score with them, and if the game slows down, then Michigan State has a clear advantage.
For the spread to be just 3.5 for a 1 vs. 9 matchup shows that oddsmakers have very little faith in the Tar Heels. They're the weakest No. 1 seed and may be playing the best team seeded sixth or worse in the tournament. If the Spartans neutralize RJ Davis, this game will be over early.
Best odds: +220 via BetMGM
Game info: Saturday at 9:40 p.m. ET, at PPG Paints Arena, Pittsburgh, Penn.
The Oregon Ducks have caught fire, and they're showing no signs of cooling off. They dropped 87 points on the South Carolina Gamecocks in Round 1. That was the third-most points allowed by the Gamecocks all season, and they play in the offensive-powered SEC.
Yet, some of our best sports betting apps still have the Ducks +220 on the moneyline to win.
Jermaine Couisnard dropped 40 points, while N'Faly Dante added 23 inside. The Creighton Bluejays will struggle to stop both of those players, even though they're allowing fewer than 70 points per game. The Ducks seem as though they've thrown out all season-long statistics and are just playing basketball.
The key to this game will be Dante vs. Ryan Kalkbrenner down low. If Dante can keep Kalkbrenner's scoring to a minimum, then the Ducks could end up with their fourth eight-plus-point victory in a row.
For even better odds on any of these three upsets, be sure to use our exclusive DraftKings promo code and get a 64% boost on any single March Madness bet!
March Madness betting odds pages
| March Madness Odds | March Madness Predictions | Final Four Odds | March Madness MVP Odds |
| March Madness Prop Bets | March Madness Upset Picks | March Madness Bracket Guide | March Madness Bracket Predictions |
| March Madness Bracket Challenges | March Madness betting promos |
Here are our best March Madness betting sites:
- Caesars Promo Code: SBRBONUS1000 | Read our Caesars Review
- BetMGM Bonus Code: SBRBONUS | Read our BetMGM Review
- bet365 Bonus Code: SBRBONUS | Read our bet365 Review
- BetRivers Promo Code: SBRBONUS | Read our BetRivers Review
- FanDuel Promo Code | Read our FanDuel Review
- DraftKings Promo Code | Read our DraftKings Review
(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.
Related pages
- Best Live Betting Sites | Best Sportsbook Promos (U.S. only)