The Louisville Cardinals and Syracuse Orange will kick off their college football seasons with an ACC tilt that could offer one of the closer games of the opening week.
Louisville finished the regular season at 6-6 last season, with an even 4-4 record in ACC play. They made a bowl game, but lost to Air Force in the First Responder Bowl. They finished under .500 for the second straight season.
Syracuse didn't have the luck in conference play to make it to a bowl game in 2021. They finished the season at 5-7, and they dropped 6 out of 8 against the ACC.
The odds are a lot tighter for this game than most of the other games happening in Week 1. This opens up the door for value in each team, depending on who you side with. Louisville is only favored by 4.5, which is -112 at FanDuel.
Louisville vs. Syracuse Matchup Information and Betting Odds
- Matchup: Louisville Cardinals (0-0) vs. Syracuse Orange (0-0)
- Venue & Location: JMA Wireless Dome (Syracuse, New York)
- Game Time: 8 p.m. Eastern Time
- Where to Watch Louisville vs. Syracuse: ACC Network