Southern California faces the favored Louisville in the 2023 Holiday Bowl at Petco Park on Wednesday, with kickoff at 8:00PM ET.
Dimers.com's in-depth betting preview for Wednesday's Louisville vs. Southern California matchup includes the latest betting odds, as well as our predictions and picks for the game.
Holiday Bowl Prediction: Who Will Win, Cover the Spread
We have used powerful machine learning and data to simulate the outcome of the 2023 Holiday Bowl 10,000 times, in keeping with our coverage of College Football picks.
Our popular predictive analytics model gives Louisville a 67% chance of beating Southern California, and our predicted final score has Louisville winning 32-24.