Southern California faces the favored Louisville in the 2023 Holiday Bowl at Petco Park on Wednesday, beginning at 8:00PM ET.
Dimers.com's full betting preview for Wednesday's Louisville vs. Southern California matchup includes the latest betting odds, as well as our predictions and picks for the game.
Holiday Bowl Prediction: Who Will Win, Cover the Spread
We have used advanced machine learning and statistics to simulate the outcome of the 2023 Holiday Bowl 10,000 times, in line with our coverage of College Football predictions.
Our leading predictive analytics model gives Louisville a 67% chance of defeating Southern California, and our predicted final score has Louisville winning 32-24.