The Los Angeles Rams (2-1) and San Francisco 49ers (1-2) will meet Monday night for the final game of Week 4. It’s a pivotal early-season divisional matchup in the NFC West. Kickoff from Levi’s Stadium will be at 8:15 p.m. ET (ESPN). Below, we analyze Tipico Sportsbook’s lines around the Rams vs. 49ers odds, and make our expert NFL picks and predictions.
The Rams are coming off a win over the Arizona Cardinals in Week 3, beating their division rivals 20-12. It was their 2nd straight win after an opening blowout loss to the Buffalo Bills. The offense is still trying to find its groove, but the defense held Arizona out of the end zone.
The 49ers will look to make it 7 wins in their last 8 games against the Rams. They had a 6-game winning streak over Los Angeles before losing in the divisional round in January, proving to have the Rams’ number in these annual matchups. San Francisco comes in with Jimmy Garoppolo at QB after losing Trey Lance for the year to an ankle injury.
FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+