The Kansas City Chiefs (1-0) kick off their 2022 homestand against the Los Angeles Chargers (1-0) Thursday at GEHA Field at Arrowhead Stadium. Kickoff time in Kansas City, Mo., is set for 8:15 p.m. ET (Prime Video). Below, we analyze Tipico Sportsbook’s lines around the Chargers vs. Chiefs odds, and make our expert NFL picks and predictions.
The Chiefs got off to a hot start in Week 1 by defeating the Arizona Cardinals 44-21. QB Patrick Mahomes won AFC Offensive Player of the Week after throwing for 360 yards and 5 TDs.
The Chargers already have a win over an AFC West rival under their belt, beating the Las Vegas Raiders 24-19 in Week 1. Chargers QB Justin Herbert threw for 279 yards and 3 TDs.
Since 1960, the Chiefs lead the all-time series over the Chargers 65-58-1. L.A. is 3-1 ATS in its last 4 games against the Chiefs. The two squads split their series straight up and against the spread 1-1 in 2021. The Chargers won 30-24 as underdogs in their 1st matchup while the Chiefs won 34-28 and covered the spread in the 2nd matchup on a Thursday night.