Lions vs Panthers Prediction, Odds & Best Prop Bets – NFL, Week 16
Lions vs Panthers Prediction, Odds & Best Prop Bets – NFL, Week 16

The Detroit Lions (7-7) visit Bank of America Stadium to take on the Carolina Panthers (5-9) on Dec. 24. Kickoff is scheduled for 1:00pm EST in Charlotte.

The Lions are betting favorites in Week 16, with the spread sitting at -2.5 (-115).

The Lions vs. Panthers Over/Under is 43.5 total points for the game.

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Lions vs. Panthers Prediction for Week 16

Based on recent trends, the winning team model predicts the Lions will win this Week 16 game with 64.0% confidence.

Based on recent against-the-spread trends, the model predicts the Lions will cover the spread this Week 16 with 54.0% confidence.

Both predictions factor in up-to-date player injuries for both the Lions and Panthers, plus offensive & defensive matchups, recent games and key player performances this season.


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Best Lions Player Prop Bets Today

We’ve highlighted some favorite NFL player prop bets for Lions players for Week 16, looking at profitable historical betting trends:

  • Jamaal Williams has hit the Receiving Yards Under in 10 of his last 12 games (+7.45 Units / 47% ROI)
  • Jared Goff has hit the Interceptions Under in his last 6 games (+6.20 Units / 84% ROI)
  • Kalif Raymond has hit the Receiving Yards Over in 7 of his last 9 games (+4.90 Units / 49% ROI)
  • Jamaal Williams has hit the Receptions Under in his last 4 games (+4.30 Units / 77% ROI)
  • Jared Goff has hit the Pass Attempts Over in his last 4 games (+4.00 Units / 90% ROI)

Best Panthers Player Prop Best Bets Today

And here are some top NFL player prop bets for Panthers players for Week 16, looking at profitable historical betting trends:

  • P.J. Walker has hit the Pass Attempts Under in 4 of his last 5 games (+2.85 Units / 42% ROI)
  • D’Onta Foreman has hit the Receiving Yards Under in 4 of his last 5 games (+2.75 Units / 43% ROI)
  • Ian Thomas has hit the Receiving Yards Under in 4 of his last 5 games at home (+2.75 Units / 41% ROI)
  • Terrace Marshall Jr. has hit the Receiving Yards Over in 6 of his last 9 games (+2.70 Units / 27% ROI)
  • P.J. Walker has hit the Completions Under in 4 of his last 5 games (+2.50 Units / 33% ROI)

  • The Detroit Lions have covered the 1H Spread in their last 9 games (+9.05 Units / 92% ROI)
  • The Detroit Lions have scored first in 11 of their last 14 games (+8.60 Units / 55% ROI)
  • The Detroit Lions have hit the Team Total Over in 12 of their last 16 games (+7.30 Units / 38% ROI)
  • The Detroit Lions have hit the 2H Moneyline in 5 of their last 6 games (+7.00 Units / 109% ROI)
  • The Detroit Lions have covered the Spread in their last 7 games (+7.00 Units / 92% ROI)

  • The Carolina Panthers have hit the 1Q Game Total Under in 11 of their last 16 games (+10.95 Units / 53% ROI)
  • The Carolina Panthers have scored first in 11 of their last 17 games (+7.85 Units / 43% ROI)
  • The Carolina Panthers have hit the 1H Moneyline in 7 of their last 12 games (+6.05 Units / 48% ROI)
  • The Carolina Panthers have hit the 2H Game Total Over in 10 of their last 15 games (+5.75 Units / 35% ROI)
  • The Carolina Panthers have hit the 1Q Moneyline in 7 of their last 15 games (+5.60 Units / 35% ROI)

Lions Against the Spread (ATS) Record

Against the spread this NFL season, the Lions have gone 10-4 (+5.5 Units / 35.71% ROI).

  • Lions are 7-7 when betting on the Moneyline for +1 Units / 6.51% ROI
  • Lions are 9-5 when betting the Over for +3.5 Units / 22.73% ROI
  • Lions are 5-9 when betting the Under for -4.9 Units / ROI

Panthers Against the Spread (ATS) Record

Against the spread this NFL season, the Panthers have gone 7-7 (-0.75 Units / -4.89% ROI).

  • Panthers are 5-9 when betting on the Moneyline for +0.25 Units / 1.67% ROI
  • Panthers are 6-8 when betting the Over for -2.85 Units / -18.45% ROI
  • Panthers are 8-6 when betting the Under for +1.4 Units / 9.12% ROI

Detroit Lions: Keys to the Game vs. the Carolina Panthers

The Lions are winless (0-4) when losing at least one fumble this season — tied for worst in NFL; League Avg: .397.

The Lions are winless (0-4) when committing 2 or more turnovers this season — tied for worst in NFL; League Avg: .302.

The Lions are 2-8-1 (.182) when within 7 points entering the 4th quarter since the 2021 season — 3rd-worst in NFL; League Avg: .494.

The Lions are winless (0-15) whe trailing at the end of the frist half since the 2021 season — tied for worst in NFL; League Avg: .237.

Carolina Panthers: Keys to the Game vs. the Detroit Lions

The Panthers are winless (0-4) when within 3 points at the two minute warning since the 2021 season — tied for worst in NFL; League Avg: .491.

The Panthers are winless (0-6) when within 3 points at the two minute warning since the 2020 season — tied for worst in NFL; League Avg: .494.

  
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