OddsJam's NFL experts take you through the betting odds, picks and predictions for this NFL preseason matchup between the Detroit Lions vs. the Indianapolis Colts on August 20, 2022 in Indianapolis. Let’s get ready for the NFL and bet on preseason football!
Lions vs. Colts Betting Odds
The Detroit Lions visit the Indianapolis Colts for this NFL matchup on August 20, 2022. Kickoff for Saturday 's game is 1:00 p.m. ET / 10:00 a.m. PT in Indianapolis.
The Detroit Lions are favored at -140 vs. the Indianapolis Colts. The Indianapolis Colts are +120 underdogs on the moneyline in this matchup and are +2.5 on the point spread at -110 .