The Detroit Lions (1-1-0) visit State Farm Stadium to take on the Arizona Cardinals (1-1-0) on Sep. 22. Kickoff is scheduled for 4:25pm EDT in Glendale, AZ.
The Lions are betting favorites in this matchup, with the spread sitting at -3 (-105).
The Lions vs. Cardinals Over/Under is 51.5 total points for the game.
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Lions vs. Cardinals Prediction
The winning team model predicts the Lions will win this game with 54.1% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
Based on recent against-the-spread trends, the model predicts the Lions will cover the spread with 61.1% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
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We’ve highlighted some favorite NFL player prop bets for Lions players this playoff game, looking at profitable historical betting trends:
Best Lions Player Prop Bets Today
- Jahmyr Gibbs has hit the Longest Rush Over in 11 of his last 12 games (+9.95 Units / 70% ROI)
- Jared Goff has hit the Rushing Yards Under in his last 8 away games (+8.00 Units / 78% ROI)
- Jahmyr Gibbs has hit the Rushing Yards Over in 12 of his last 17 games (+6.55 Units / 34% ROI)
- Jahmyr Gibbs has hit the Longest Reception Under in 8 of his last 9 games (+6.45 Units / 53% ROI)
- Jared Goff has hit the Passing Yards Over in 13 of his last 19 games (+6.45 Units / 31% ROI)
And here are some top NFL player prop bets for Cardinals players for this matchup, looking at profitable historical betting trends:
Best Cardinals Player Prop Best Bets Today
- James Conner has hit the Longest Reception Under in 7 of his last 8 games (+5.75 Units / 58% ROI)
- James Conner has hit the Longest Rush Over in his last 5 games (+5.00 Units / 85% ROI)
- Chris Moore has hit the Receiving Yards Over in 6 of his last 7 games (+4.85 Units / 58% ROI)
- Zay Jones has hit the Receptions Over in 5 of his last 6 games (+4.05 Units / 57% ROI)
- Chris Moore has hit the Longest Reception Over in 5 of his last 6 games (+3.85 Units / 55% ROI)
Lions Best Bets:
- The Detroit Lions have covered the Spread in 16 of their last 21 games (+10.50 Units / 45% ROI)
- The Detroit Lions have hit the 3Q Game Total Over in 14 of their last 19 games (+8.55 Units / 38% ROI)
- The Detroit Lions have covered the 1H Spread in 15 of their last 21 games (+8.20 Units / 35% ROI)
- The Detroit Lions have hit the 1Q Game Total Over in 8 of their last 10 away games (+6.90 Units / 59% ROI)
- The Detroit Lions have hit the Moneyline in 15 of their last 21 games (+6.60 Units / 15% ROI)
Cardinals Best Bets:
- The Arizona Cardinals have hit the 2H Moneyline in 6 of their last 8 games (+7.10 Units / 89% ROI)
- The Arizona Cardinals have hit the Game Total Over in 7 of their last 9 games at home (+4.80 Units / 48% ROI)
- The Arizona Cardinals have hit the 2Q Game Total Over in 11 of their last 17 games (+4.55 Units / 24% ROI)
- The Arizona Cardinals have scored last in 5 of their last 7 games at home (+4.35 Units / 60% ROI)
- The Arizona Cardinals have hit the Team Total Over in 6 of their last 8 games at home (+4.05 Units / 41% ROI)
Lions Against the Spread (ATS) Record
Against the spread this NFL preseason, the Lions went 1-1 (-0.1 Units / -4.55% ROI).
- Lions are 1-1 when betting on the Moneyline for -2.6 Units / -43.33% ROI
- Lions are 0-2 when betting the Over for -2.25 Units / -100% ROI
- Lions are 2-0 when betting the Under for +2 Units / ROI
Cardinals Against the Spread (ATS) Record
Against the spread this NFL preseason, the Cardinals went 2-0 (+2 Units / 90.91% ROI).
- Cardinals are 1-1 when betting on the Moneyline for +0 Units / 0% ROI
- Cardinals are 2-0 when betting the Over for +2 Units / 90.91% ROI
- Cardinals are 0-2 when betting the Under for -2.2 Units / -100% ROI
Detroit Lions: Keys to the Game vs. the Arizona Cardinals
The Lions were undefeated (5-0) when allowing less than 5 explosive passes last season — T-best in NFL; League Avg: .574.
The Lions are 12-3 (.800) when allowing less than 3 sacks since the 2023 season — T-6th-best in NFL. The Cardinals have averaged just 2.1 sacks per game over that time span — T-3rd-worst in NFL.
The Lions were undefeated (5-0) after a loss last season — T-best in NFL; League Avg: .488.
The Lions were 3-2 (.600) when rushing less than 25 times last season — 2nd-best in NFL; League Avg: .276.
Arizona Cardinals: Keys to the Game vs. the Detroit Lions
The Cardinals were winless (0-3) when forcing 2 or more turnovers last season — worst in NFL; League Avg: .707.
The Cardinals are winless (0-3) when forcing 2 or more turnovers since the 2022 season — worst in NFL; League Avg: .710.
The Cardinals were 1-6 (.143) when sacking the QB 3 or more times last season — 2nd-worst in NFL; League Avg: .650.
The Cardinals were winless (0-10) when scoring less than 22 points last season — T-worst in NFL; League Avg: .253.
Additional Matchup Notes for Detroit Lions vs. Arizona Cardinals
The Cardinals have been successful on 50.0% of plays they have ran against a light rush since the 2023 season — 4th-best in NFL. The Lions have allowed their opponents to be successful on 54.5% of plays with a light rush since the 2023 season — 2nd-worst in NFL.