The last time Houston made the Final Four was the 2020-21 season when the Cougars lost to Baylor 78-59.
Houston was a No. 2 seed, while Baylor was a No. 1.
The 2023 Final Four will be held at NRG Stadium in Houston.
Houston NCAA Tournament History
| Year | NCAA Tournament Result |
| 2021-22 | Lost NCAA Tournament Regional Final |
| 2020-21 | Lost NCAA Tournament National Semifinal |
| 2019-20 | Did Not Qualify |
| 2018-19 | Lost NCAA Tournament Regional Semifinal |
| 2017-18 | Lost NCAA Tournament Second Round |
| 2016-17 | Did Not Qualify |
| 2015-16 | Did Not Qualify |
| 2014-15 | Did Not Qualify |
| 2013-14 | Did Not Qualify |
| 2012-13 | Did Not Qualify |
| 2011-12 | Did Not Qualify |
| 2010-11 | Did Not Qualify |
| 2009-10 | Lost NCAA Tournament First Round |
| 2008-09 | Did Not Qualify |
| 2007-08 | Did Not Qualify |
| 2006-07 | Did Not Qualify |
| 2005 -06 | Did Not Qualify |
| 2004-05 | Did Not Qualify |
| 2003-04 | Did Not Qualify |
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