These are two teams trending in completely different directions at the moment. On one hand, the 49ers suddenly have life in the NFC West after acquiring Christian McCaffrey and seemingly getting healthy at the right time. The same can’t be said of the Chargers, who are struggling mightily on offense due to numerous injuries to their skill position players. Justin Herbert has been left out to dry at times, but the young gunslinger has still managed to lead his team to a winning record to this point.
Our NFL expert has picks, predictions and best bets for this matchup, so let’s break it all down.
Be sure not to miss any of our'NFL picks'for Week 10 – we're 76-58-3 on spreads this season (+21.2 units!)
NFL Week 10 Los Angeles Chargers vs San Francisco 49ers prediction
We’re expecting points to be scored in this matchup, and it wouldn’t be surprising if the 49ers attacked a Chargers run defense that is still struggling. Despite its best efforts in the offseason, this Los Angeles defense has not been stout, which could be a major issue against a 49ers offense that has a ton of talent and versatility across the board. With a raucous crowd expected for Sunday Night Football, this one could get away from the visitors if they aren’t careful. This should be a fascinating contest, so let’s get into our expert’s predictions.