The James Madison Dukes (5-2) visit Cardinal Stadium to take on the Louisville Cardinals (5-3) on Nov. 5. Kickoff is scheduled for 7:30pm EDT in Louisville.
Louisville are betting favorites in Week 10, with the spread sitting at -7.5 (-110).
The Over/Under for James Madison vs. Louisville is 52.5 total points.
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James Madison vs Louisville Prediction for Week 10
Based on recent trends, the winning team model predicts Louisville will win this game with 61.9% confidence.
James Madison vs Louisville Spread Prediction for Week 10
Based on recent against-the-spread trends, the model predicts James Madison will cover the spread with 51.6% confidence.
Both predictions factor in up-to-date player injuries for both James Madison and Louisville, plus offensive & defensive matchups, recent games and key player performances this season.
Louisville Best Bets & Trends for ATS, Moneyline & Totals
- Louisville has hit the 1Q Game Total Over in 12 of their last 18 games (+8.60 Units / 42% ROI)
- Louisville have covered the 1H Spread in 12 of their last 19 games (+4.35 Units / 21% ROI)
- Louisville has hit the 1H Game Total Under in 6 of their last 8 games (+3.75 Units / 42% ROI)
- Louisville has hit the Team Total Over in 8 of their last 12 games (+3.45 Units / 25% ROI)
- Louisville has hit the 1H Moneyline in 4 of their last 6 games (+3.10 Units / 26% ROI)
James Madison Against the Spread (ATS) Record
James Madison has gone 0-0 against the spread this college football season (+0 Units / 0% ROI).
- James Madison is 0-0 when betting on the Moneyline for +0 Units / 0% ROI
- James Madison is 0-0 when betting the Over for +0 Units / 0% ROI
- James Madison is 0-0 when betting the Under for +0 Units / 0% ROI
Louisville Against the Spread (ATS) Record
Louisville has gone 5-3 against the spread this college football season (+1.75 Units / 20% ROI).
- Louisville is 5-3 when betting on the Moneyline for -1.85 Units / -10.36% ROI
- Louisville is 4-4 when betting the Over for -0.4 Units / -4.55% ROI
- Louisville is 4-4 when betting the Under for -0.4 Units / -4.55% ROI
James Madison is winless (0-1) when not forcing a fumble — tied for worst in FBS; Average: .442
James Madison is winless (0-1) when allowing 100 or more rushing yards — tied for worst in FBS; Average: .393
James Madison is winless (0-2) when allowing 22 or more points — tied for worst in FBS; Average: .283
Louisville is 4-15 (.211) when the opposing team converts 55% or more of its red zone chances into touchdowns since the 2020 season– 6th-worst among Power 5 Teams; Average: .434
Louisville is 4-13 (.235) when allowing an average of more than 5 yards on first down plays since the 2020 season– 8th-worst among Power 5 Teams; Average: .428
Louisville is 1-7 (.125) when not forcing a fumble — 6th-worst among Power 5 Teams; Average: .453
Louisville is 4-13 (.235) when allowing 200 or more passing yards since the 2020 season– 6th-worst among Power 5 Teams; Average: .465